人畜共患病原体的多药耐药:药用植物是一种治疗选择吗?

M. Spînu, M. Niculae, S. Popescu, E. Páll, C. Sandru
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引用次数: 0

摘要

多药耐药(MDR)是一种复杂的现象,它不仅是由人类和动物药物中的非歧视性抗生素治疗引起的,而且是由耐药基因在不同细菌之间的转移引起的。除了不同的环境外,动物还体现了耐药微生物群发展的生态位,这不仅对接触者,而且对消费者/游客构成严重威胁。耐多药细菌的流行周期因其宿主或其栖息地的变化而结束。为了防止耐多药的进一步传播,研究了天然溶液的功效,包括从药用植物中分离的各种化合物(醌类、黄酮类、黄酮类和黄酮醇类、单宁类、香豆素类、萜类和精油、生物碱、凝集素和多肽等)。这些研究的结果对医学来说是有价值的,但是药用植物能弥补人类、动物和环境的空白吗?本章旨在试图回答这个问题。
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Multidrug Resistance in Zoonotic Pathogens: Are Medicinal Plants a Therapeuthic Alternative?
Multidrug resistance (MDR) represents a complex phenomenon, caused not only by nondiscriminative antibiotic therapy in both human and animal medicine but also by the transfer of resistance genes between different bacteria. Animals besides different environ- ments embody a niche for the development of resistant microbiomes, representing a serious threat to people not only as contacts but also as consumers/tourists. The epidemi- ological cycle of MDR bacteria is closed by changes in either their hosts or in their habitats. To prevent further spreading of MDR, natural solutions are investigated as efficacy, including in this category various compounds isolated from medicinal plants (quinones, flavones, flavonoids, and flavonols, tannins, coumarins, terpenoids and essential oils, alkaloids, lectins and polypeptides, etc.). The results of such studies are valuable for the medicine, but could the medicinal plants cover the gap for humans, animals, and the environment? This chapter aims at trying to answer this question.
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Development of Antibiotic Resistance in Wastewater Treatment Plants Introductory Chapter: Stepping into the Post-Antibiotic Era— Challenges and Solutions Multidrug Resistance in Zoonotic Pathogens: Are Medicinal Plants a Therapeuthic Alternative? Antimicrobial Resistance of Common Zoonotic Bacteria in the Food Chain: An Emerging Threat Antibiotic Use in Poultry Production and Its Effects on Bacterial Resistance
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