The Perspective of Chemodynamic Therapy Combination with Plasma in Cancer Treatments

Chemodynamic therapy is (CDT) a novel emerging cancer treatment based on the Fenton-Fenton like reactions. During the Fenton chemical process, hydrogen peroxide in the presence of iron is converted to hydroxyl radical which is a highly reactive species to induce cell damage. The tumor optimal conditions for the occurrence of the Fenton-Fenton like reaction are: a high concentration of hydrogen peroxide, low pH level, and low Glutathione concentration. The requirement for these conditions limit us to achieving the best results from cancer chemodynamic therapy, thus combination with other treatments may be necessary. Here, using current research and a cell model, firstly we introduce the limitations of chemodynamic therapy in cancer treatment and then propose that cold atmospheric plasma could be a suitable candidate for combination with chemodynamic therapy to overcome these limitations.