使用基于Mc-10镁合金的生物惰性和可生物降解植入物钉入患者后炎症过程的进展

E. V. Yatsun, G. Prozorova, V. Chorny, M. Golovakha, D. V. Ivchenko
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引用次数: 0

摘要

总结。现代医学广泛使用人造材料来代替受损的组织和器官。生物可降解植入物应逐渐被活组织所取代,并在一定时间内保持功能,对周围组织和人体一般不会产生任何负面影响。临床研究的生化值指定炎症反应强度的IM钉与生物可降解的植入物是临床和科学的兴趣。研究任务:验证可生物降解镁合金MS-10植入物在胫骨骨干骨折动态内钉中的应用。材料和方法。该研究涉及34例胫骨骨干骨折患者,类似于手术治疗(IM钉)。髓内空心钛钉作为阻塞针。治疗包括闭合复位后胫骨内钉。为了锁定钉子,16例患者将MS-10镁合金制成的螺钉插入静态(圆)孔中。在18例患者中,将钛制成的螺钉插入静态孔中。两组患者分别在手术前后、术后2周和4周、术后2月和4个月进行采血研究。血液生化试验测定血浆中纤维蛋白原单体复合物的浓度(β-萘酚试验)。结果。对AST和ALT活性的研究发现,与使用生物惰性螺钉锁定IM钉的患者相比,使用生物可降解螺钉的患者AST和ALT活性较低(19%和29%)。两组患者血液ESR、纤维蛋白原B和总胆红素的情况相似。结论。该研究令人信服地证明了生物可降解材料(MS-10镁合金)用于长骨骨折患者内钉植入物的方便性。
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PROGRESSION OF INFLAMMATORY PROCESSES IN PATIENTS AFTER IM NAILING USING BIOINERT AND BIODEGRADABLE IMPLANTS BASED ON MC-10 MAGNESIUM ALLOY
Summary. Modern medicine widely uses artificial materials to replace damaged tissues and organs. Biodegradable implants should be gradually replaced with living tissue and stay functioning within a specified period, don’t have any negative impact on surrounding tissues and a human body in general. Clinical studies of biochemical values specifying the intensity of inflammatory response to IM nailing with biodegradable implants are of clinical and scientific interest. Task of the study: to substantiate of the use of implants made of biodegradable magnesium alloy MS-10 in the dynamic IM nailing for diaphyseal fractures of the tibia. Materials and methods. The study involved 34 patients with diaphyseal tibial fractures, which resembled surgical treatment (IM nailing). Cannulated intramedullary titanium nails served as a blocking pin. The treatment included closed reposition followed with IM nailing of a tibia. To lock the nail, a screw made of magnesium alloy MS-10 was inserted in a static (round) hole in 16 patients. In 18 patients, a screw made of titanium was inserted into a static hole. The both groups passed blood sampling for studies, before and after the surgery, 2 and 4 weeks, 2 and 4 months after surgery. Biochemical blood tests were to determine the concentration of fibrinogen-monomer complexes in the blood plasma (β-naphthol test). Results. The study of the activity of AST and ALT found it lower (19 and 29%) in patients with biodegradable screws, compared to the group of patients with IM nailing locked with bioinert screws. The situation was similar with ESR, fibrinogen B and total bilirubin in the blood of patients in both groups. Conclusions. The study convincingly proves the expediency of the use of biodegradable material (magnesium alloy MS-10) to produce implants for the IM nailing for the patients with long bones’ fractures.
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