不同ph值下8-溴腺苷的合成

SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2 Pub Date : 2021-05-20 DOI:10.46646/sakh-2021-2-132-135

M. Khancheuski, V. N. Lesik, E. Kvasyuk

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摘要

8-溴腺苷是合成嘌呤、核苷和核苷酸类似物的重要中间体，具有广泛的生物活性。研究了培养基的pH值对8-溴腺苷产率的影响。结果表明，在pH 4.3的条件下，腺苷与溴水溶液反应制备8-溴腺苷的最佳条件。

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SYNTHESIS OF 8-BROMOADENOSINE AT DIFFERENT PH VALUES

This article shows methods for the preparation of 8-bromoadenosine which is an important intermediate in the syntheses of analogs of purines nucleosides and nucleotides with a broad spectrum of biological activity. The influence of the pH values of the medium on the yield of 8-bromoadenosine was studied. It was showed that pH 4.3 is optimal for the preparation of 8-bromoadenosine by reaction of adenosine with a solution of bromine in water.

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SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2

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