Oral proliferative verrucous leukoplakia with oral submucous fibrosis treated with CO2laser

Oral leukoplakia is one of the most common physiologic as well as pathologic white lesion in the oral cavity. Of the many variants, oral proliferative verrucous leukoplakia (OPVL) is a rare clinicopathological entity of unknown etiology. OPLV initially develops as a white hyperkeratotic plaque that eventually becomes a multifocal disease with confluent, exophytic and proliferative features. Published case series with long-term follow-up describes OPVL as a disease with aggressive biological behavior due to its high probability of recurrence and a high rate of malignant transformation. This article describes a rare case report of OPVL associated with oral submucous fibrosis in the light of current information with clinical and histological aspect in a young patient, which was successfully treated with CO2Laser.