Analysis of the Efficacy of mNGF Combined with ACDF Surgery in The Treatment of Cervical Spinal Cord Injury Without Fracture and Dislocation

Objective: Analysis of the efficacy of mNGF combined with ACDF surgery for cervical spinal cord injury without fracture and dislocation compared to ACDF surgery alone for cervical spinal cord injury without fracture and dislocation. Methods: 50 patients of cervical spinal cord injury without fracture and dislocation admitted to the Department of Orthopaedics of the First Affiliated Hospital of Hebei North University from January 2019 to January 2021 were selected. The 27 patients treated with ACDF surgery were recorded as group A, and the 23 patients treated with mNGF combined with ACDF surgery were recorded as group B. JOA scores at admission, 1 month, 3 months, and 6 months after surgery, and ASIA grading at admission and at the end follow-up at 6 months after surgery were recorded for each group. Results: There was no statistical difference between the admission JOA score and ASIA grading of patients in groups A and B at P > 0.05. At 1 month, 3 months and 6 months after surgery, the JOA scores and ASIA grading at the end follow-up at 6 months after surgery were compared between the two groups, P< 0.05, and there were statistical differences in JOA scores at 1 month, 3 months and 6 months after surgery and ASIA grading at 6 months after surgery between the two groups of patients in A and B. Conclusion: The mNGF combined with ACDF surgery is safe, feasible and effective in the treatment of cervical spinal cord injury without fracture and dislocation. The combination of the two accelerates surgical recovery and has better clinical outcomes.