2019-2021年巴基斯坦丁型肝炎病毒和糖尿病患者中乙型肝炎病毒感染的患病率

R. Ahmad, Mazhar Muhammad Waqar, Saif Saira, Sikandar Mudasara, Mehmood Javaria, Iram Wajeeha, Tahir Hira, Noor Shanzab, Mazhar Fatima
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The sera of the patient’s sample were examined to analyze the LFTs, HBS serology, HBS ELIZA, anti-HBeAg, AFP, anti- HDV, HBC IgM, and HBV DNA EAL TIME PCR. An anticoagulant sample was used to analyze their prothrombin time, HB level, WBC count, PLT counts, and HBA1C. Data were analyzed by using Microsoft Excel 2019 and SPSS version 14.0. Results: 975 samples were collected from the Multan district of Punjab. Out of which 638(65.43%) patients were detected positive for HBsAg serology, 312(32.84%) were not detected. The HBA1C test values are higher in HBV patients and its normal value is below 6.4%. In 1st group 258 patients out of 638 are HBV PCR DETECTED, bilirubin 2.1+-5.7, ALP 425.1±575.1, AST 119.6±102.6, ALT 62.0±41.6, and albumin 3.5±0.9. in the 2nd group, 149 patients out of 638 are HBV PCR detected, bilirubin 1.4±1.9, ALP 488.1±339.2, AST 143.0±117.4, ALT 78.1±53.4, and albumin 4.4±0.6. 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引用次数: 1

摘要

乙型肝炎病毒有包膜蛋白包裹着核酸,起到保护作用。乙型肝炎DNA病毒属于肝病毒科,与逆转录病毒相似。在全球范围内,乙肝病毒感染者约为20亿人,其中约3.5亿人为慢性携带者。每年有100万人死于乙肝病毒。拉丁美洲每年报告40万新病例。在世界范围内,巴基斯坦被认为是最大的慢性病毒性肝炎感染国家之一。方法:对旁遮普省南部不同地区的975个样本进行重新编码。检测患者血清LFTs、HBS血清学、HBS elisa、抗hbeag、AFP、抗HDV、HBC IgM、HBV DNA EAL TIME PCR。使用抗凝血样品分析他们的凝血酶原时间、HB水平、WBC计数、PLT计数和HBA1C。数据分析采用Microsoft Excel 2019和SPSS 14.0。结果:在旁遮普省木尔坦地区采集样本975份。血清HBsAg阳性638例(65.43%),未检出312例(32.84%)。HBV患者HBA1C检测值较高,正常值低于6.4%。第一组638例患者中HBV PCR检出258例,胆红素2.1+-5.7,ALP 425.1±575.1,AST 119.6±102.6,ALT 62.0±41.6,白蛋白3.5±0.9。第二组638例患者中HBV PCR检出149例,胆红素1.4±1.9,ALP 488.1±339.2,AST 143.0±117.4,ALT 78.1±53.4,白蛋白4.4±0.6。结论:糖尿病患者的HBV感染率高于糖尿病对照组。血清AFP水平高的患者倾向于hbs - ag阳性,而AFP水平低的患者与隐源性肝硬化相关。与hdv阳性病例相比,抗hdv阴性病例的HBc IgM阳性较高。HBV DNA值在抗HBV阴性病例中较高。HBsAg与HBV DNA水平相关,it期较高,IC期较低。
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Prevalence of hepatitis B virus infection among persons with hepatitis D virus and diabetes mellitus in Pakistan, 2019-2021
Introduction: The HBV virus has its enveloped protein that surrounds nucleic acid for its protection. Hepatitis B DNA virus belongs to the Hepadnoviridae family and is similar to retroviruses. Globally, HBV infected people approximately 2 billion in the world, about 350 million people were chronic carriers. One million deaths are caused by the HBV virus every year. Each year, 400,000 new cases were reported in Latin America. Among all over the World, Pakistan was considered as one of the largest chronic viral hepatitis infection countries. Methodology: 975 samples were recoded from different districts of south Punjab. The sera of the patient’s sample were examined to analyze the LFTs, HBS serology, HBS ELIZA, anti-HBeAg, AFP, anti- HDV, HBC IgM, and HBV DNA EAL TIME PCR. An anticoagulant sample was used to analyze their prothrombin time, HB level, WBC count, PLT counts, and HBA1C. Data were analyzed by using Microsoft Excel 2019 and SPSS version 14.0. Results: 975 samples were collected from the Multan district of Punjab. Out of which 638(65.43%) patients were detected positive for HBsAg serology, 312(32.84%) were not detected. The HBA1C test values are higher in HBV patients and its normal value is below 6.4%. In 1st group 258 patients out of 638 are HBV PCR DETECTED, bilirubin 2.1+-5.7, ALP 425.1±575.1, AST 119.6±102.6, ALT 62.0±41.6, and albumin 3.5±0.9. in the 2nd group, 149 patients out of 638 are HBV PCR detected, bilirubin 1.4±1.9, ALP 488.1±339.2, AST 143.0±117.4, ALT 78.1±53.4, and albumin 4.4±0.6. Conclusion: The prevalence of HBV in diabetic patients is higher as compared to control diabetic patients. the patients with high serum AFP levels tend to be HBs-Ag-positive, and those who have low AFP levels are associated with cryptogenic cirrhosis. The positive HBc IgM is higher in anti-HDV-negative cases as compared to HDV-positive cases. The value of HBV DNA was higher in anti-HDV-negative cases. The HBsAg correlates with HBV DNA level and it’s a level higher in the IT phase and lowers in the IC phase.
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