烧伤患者分离细菌的发生率、临床评价及抗生素谱分析

Aliya Raza, Muhammad Ibrahim, Romah Ishfaq, Iqra Saleem, Muhammad Awais Altaf, Umema Asmat
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摘要

背景:微生物污染在控制烧伤患者住院治疗的结果和时间跨度中起着显著作用。因此,必须定期监测微生物及其耐药模式。耐多药细菌(MDR)的出现促使研究人员制定新的计划来对抗这种威胁。目的:对烧伤患者感染菌进行评估,了解分离菌的耐药情况,确定抗生素对烧伤患者感染菌的抗菌效果。方法:在2019年1月至2019年4月进行描述性案例系列研究并收集定量数据。从木尔坦Pak Italian烧伤科收治的200例烧伤患者中收集样本,按照CLSI(临床和实验室标准协会)指南进行培养、细菌鉴定和抗生素敏感性测试。结果:革兰氏阴性菌189株(94.5%),革兰氏阳性菌11株(5.5%)。分离到的微生物为普通变形杆菌53株(26.5%)、大肠杆菌47株(23.5%)、铜绿假单胞菌45株(22.5%)、肠杆菌44株(22%)和金黄色葡萄球菌11株(5.5%)。抗生素敏感性分别为亚胺培南156(78%)、美罗培尼150(75%)、莫西沙星17(8.5%)、左氧氟沙星67(33.5%)、哌拉西林/他唑巴坦123(61.5%)、氧氟沙星22(11%)、阿米卡星16(8%)。实际意义:我们的研究结果可以帮助所有医护人员选择新的抗生素方案,在所有类型的烧伤患者中显著下降,并且我们能够降低这类患者的死亡率。明确的传染限制有助于限制疾病和耐多药病原体的增殖。结论:本研究是成功的,因为抗生素相关并发症明显减少,所有类型的烧伤患者的死亡率也有所下降。关键词:抗生素谱,烧伤,临床评价,感染,耐多药,死亡率。
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Incidence, Clinical Evaluation and Antibiogram of Bacterial Isolates Obtained from Burn Patients
Background: Microbiological contamination plays salient role in governing the outcome and time span in the hospital for burn victims in burn unit. Therefore, regular supervision of microbes and its resistance pattern is mandatory. The emergence of Multi Drug Resistant (MDR) bacteria provoked researchers to develop new plans to combat against the threat. Objective: To assess the infectious organisms, to know the drug resistance of isolates and ascertain the effectiveness of antibiotics against microbes that are found in burn patients. Methodology: Descriptive case series study performed and Quantitative data was collected in Jan 2019 to April 2019. Two hundred sample from burn patients admitted in Pak Italian Burn Unit Multan was collected, processed for culture, bacterial identifications and to test the antibiotics sensitivity in accordance with CLSI (clinical and laboratory standards institute) guidelines. Results: Gram negative bacteria were 189 (94.5%) and gram positive were 11 (5.5%).Organisms isolated were Proteus vulgaris 53 (26.5%) followed by Escherichia coli 47 (23.5%), Pseudomonas aeruginosa 45 (22.5%), Enterobacter 44 (22%) and Staphylococcus aureus 11 (5.5%). Imipenem 156 (78%), Meropenem150 (75%), Moxifloxacin 17(8.5%), Levofloxacin 67 (33.5%), Piperacillin/Tazobactam 123 (61.5%), Oxifloxacin 22 (11%) and Amikacin 16 (8%) were used for antibiotic sensitivity. Practical implication: Our study results can helpful for all health care personals to select new regime of antibiotics which significantly declined in all types of burn patients and also we are able to decrease the mortality rate in such patients. Assertive contagion limitations can helpful in confining the disease and proliferation of MDR pathogens. Conclusion: This study proved to be successful because antibiotic associated complications were decreased significantly as a result mortality rate declination was also noticed in all the types of burn patients. Keywords: Antibiogram, Burn, Clinical evaluations, Infection, Multi drug resistance (MDR), Mortality.
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