Y. Ogra, Shunji Nagasaki, A. Yawata, Yasumi Anan, Koichi Hamada, A. Mizutani
{"title":"金属组学方法研究成纤维细胞向脂肪细胞分化过程中元素浓度的变化。","authors":"Y. Ogra, Shunji Nagasaki, A. Yawata, Yasumi Anan, Koichi Hamada, A. Mizutani","doi":"10.2131/jts.41.241","DOIUrl":null,"url":null,"abstract":"We aimed to establish an element array analysis that involves the simultaneous detection of all elements in cells and the display of changes in element concentration before and after a cellular event. In this study, we demonstrated changes in element concentration during the differentiation of 3T3-L1 mouse fibroblasts into adipocytes. This metallomics approach yielded unique information of cellular response to physiological and toxicological events.","PeriodicalId":231048,"journal":{"name":"The Journal of toxicological sciences","volume":"38 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Metallomics approach to changes in element concentration during differentiation from fibroblasts into adipocytes by element array analysis.\",\"authors\":\"Y. Ogra, Shunji Nagasaki, A. Yawata, Yasumi Anan, Koichi Hamada, A. Mizutani\",\"doi\":\"10.2131/jts.41.241\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We aimed to establish an element array analysis that involves the simultaneous detection of all elements in cells and the display of changes in element concentration before and after a cellular event. In this study, we demonstrated changes in element concentration during the differentiation of 3T3-L1 mouse fibroblasts into adipocytes. This metallomics approach yielded unique information of cellular response to physiological and toxicological events.\",\"PeriodicalId\":231048,\"journal\":{\"name\":\"The Journal of toxicological sciences\",\"volume\":\"38 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of toxicological sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2131/jts.41.241\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of toxicological sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2131/jts.41.241","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Metallomics approach to changes in element concentration during differentiation from fibroblasts into adipocytes by element array analysis.
We aimed to establish an element array analysis that involves the simultaneous detection of all elements in cells and the display of changes in element concentration before and after a cellular event. In this study, we demonstrated changes in element concentration during the differentiation of 3T3-L1 mouse fibroblasts into adipocytes. This metallomics approach yielded unique information of cellular response to physiological and toxicological events.
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