关岛肌萎缩性侧索硬化症和帕金森-痴呆的模式。

Contemporary neurology series Pub Date : 1975-01-01
J A Brody, J M Stanhope, L T Kurland
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引用次数: 0

摘要

自1950年代初以来,关岛查莫罗人中肌萎缩性侧索硬化症和帕金森氏痴呆症的惊人集中引起了人们的注意。过去20年进行的广泛研究没有揭示这些疾病的原因以及这些疾病在关岛显著集中的原因。大约十分之一的25岁以上的古巴人死于ALS,另外十分之一的人死于PD。肌萎缩性侧索硬化症在关岛发生的频率仍然是美国大陆的大约50倍。病毒学和生物化学技术的进步,以及多年的研究,似乎正在把我们引向一些问题将得到解决的方向。我们将尝试审查有关的背景资料,并总结迄今为止的数据和观察结果。
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Patterns of Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia on Guam.

The striking concentration of amyotrophic lateral sclerosis (ALS) and parkinsonismdementia (PD) among the Chamorro people of Guam has attracted attention since the early 1950's. Extensive studies conducted over the past 20 years have not revealed the causes of these diseases and the reasons for their remarkable concentrations on Guam. Approximately 1 in 10 Guamanian deaths over age 25 is from ALS, and another 1 in 10 is from PD. ALS still occurs approximately 50 times more frequently on Guam than in the continental United States. Advances in virologic and biochemical techniques, and long years of study, appear to be leading us to a point where some of the problems will be resolved. We shall attempt to review the pertinent background information and summarize the data and observations up to the present time.

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