13- bromommonocillin I:一种新的WNT-5A表达抑制剂，由衣原孢Pochonia chlamydosporia变种

Natural Product Updates Pub Date : 2009-11-01 DOI:10.3987/COM-09-11809

H. Shinonaga, N. Sakai, Y. Nozawa, A. Ikeda, M. Aoki, A. Kawashima

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引用次数: 2

摘要

WNT-5A是一种与真皮乳头细胞增殖有关的分泌性糖蛋白。在寻找WNT-5A表达抑制剂的过程中，从真菌衣孢Pochonia chlamydosporia发酵液中分离到一种新的化合物13-bromomonocillin I(1)，并在添加nabr的培养基中培养。13-Bromomonocillin I(1)具有抑制WNT-5A表达的活性，ic50值为0.25 μM。

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13-Bromomomonocillin I: a new WNT-5A expression inhibitor produced by Pochonia chlamydosporia var. chlamydosporia

WNT-5A is a secretory glycoprotein related to the proliferation of dermal papilla cells. While searching for an inhibitor of WNT-5A expression, a new compound, 13-bromomonocillin I (1), was isolated from the fermentation broth of the fungus Pochonia chlamydosporia, cultured in NaBr-supplemented medium. 13-Bromomonocillin I (1) exhibited WNT-5A expression inhibitory activity with an IC 50 value of 0.25 μM.

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