ELBW婴儿PDA关闭:是否,何时以及如何做

S. Whiting, S. Sathanandam
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引用次数: 1

摘要

动脉导管未闭(PDA)是困扰早产儿尤其是极低出生体重儿(ELBW)的最常见的心血管疾病。尽管五十年的科学研究已经产生了成千上万的出版物,包括超过65个随机对照试验,心脏病学家,新生儿学家和外科医生仍然无法回答一些简单的问题,例如是否,何时以及如何关闭ELBW婴儿的PDA。本章将检查现有的证据,以回答这些基本问题。本章将特别关注经导管PDA闭合(TCPC),这虽然是一种新的治疗方法,但在未来已经显示出巨大的潜力,成为最好的治疗选择。现在是时候让所有专科的医生聚集在一起,整合证据,为患有血流动力学显著PDA的ELBW婴儿制定一种管理算法。
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PDA Closure in ELBW Infants: If, When, and How to Do It
Patent ductus arteriosus (PDA) is the most common cardiovascular condition afflicting premature neonates especially those born extremely low birth weight (ELBW). Despite five decades of scientific inquiry which has produced thousands of publications including over 65 randomized controlled trials, cardiologists, neonatologists, and surgeons still cannot answer simple questions such as if, when and how to close to the PDA in ELBW infants. This chapter will examine current evidence in order to answer these fundamental questions. The chapter will specifically focus on transcatheter PDA closure (TCPC), which albeit a new therapy, has displayed great potential to be the best therapeutic option in the future. It is about time that physicians from all sub-specialties come together and integrate the evidence to develop a management algorithm for ELBW infants with hemodynamically significant PDA.
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