儿科开颅术后镇痛:三级医院的经验

Erika León-Álvarez, Janet Gloria Ortiz-Bautista, Columba Ortega-Munguía, C. Murata
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摘要

. 导言:仍然有一种观点认为,患者在颅内手术后不会经历剧烈的疼痛。与疼痛相关的交感神经刺激可导致颅内压升高和术后出血。关于在开颅手术中使用阿片类药物进行术后镇痛存在争议,因为担心其副作用,这可能掩盖神经系统改变的迹象。关于小儿开颅后镇痛的研究有限。目的:探讨丁丙诺啡联合酮罗拉酸和昂丹司琼对小儿开颅术后疼痛的控制效果。方法:描述性队列研究。术后持续输注丁丙诺啡、酮咯酸、昂丹司琼30小时,以控制疼痛。研究的主要变量为注射开始时、4小时、8小时、12小时、24小时和30小时的疼痛、血流动力学变量和镇静深度。结果:纳入109例患者。71.56%的患者疼痛控制充分,28.4%的患者疼痛控制不足,差异有统计学意义(p < 0.001)。5.6%的患者在输注开始和24小时(4.5%)有中度镇静,对血流动力学变量没有显著影响。恶心占8.2%,呕吐占6.64%。未出现深度镇静或呼吸抑制。结论:该方法是治疗小儿开颅术后疼痛的有效方法。
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Analgesia postoperatoria para craneotomías en pediatría: experiencia en un Hospital de Tercer Nivel
. Introduction: There is still a belief that patients do not experience intense pain after intracranial surgery. Sympathetic stimulation associated with pain can lead to elevated intracranial pressure and postoperative haemorrhage. There is controversy about the use of opioids for postoperative analgesia in craniotomies, owing to fear of its side effects, which can mask signs of neurological alteration. There are limited studies in the pediatric patient for post-craniotomy analgesia. Objective: To describe the postcraneotomies pain control level, using buprenorphine in partnership with ketorolac and ondansetron in pediatric patients. Methods: Descriptive cohort study. For postoperative pain control, patients were given continuous infusion buprenorphine, ketorolac and ondansetron for 30 hours. The main variables to investigate were pain at beginning of infusion, at four, eight, 12, 24 and 30 hours, hemodynamic variables and depth of sedation. Results: 109 patients were included. Adequate control of pain was observed in 71.56% of patients, whereas in 28.4% insufficient control was found, with a statistically significant difference (p < 0.001). There was moderate sedation in 5.6% of the patients at the start of infusion and at 24 hours (4.5%), without significant impact on hemodynamic variables. Nausea was found in 8.2% and vomiting in 6.64%. No deep sedation, or respiratory depression was presented. Conclusions: These findings suggest that is an effective option to treat postcraneotomy pain in pediatric patients.
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