新生儿右、左侧胸内定位肝膈疝的治疗效果

O. Mokrushina, A. Razumovskiy, E. V. Yudina, I. Afukov, V. Shumikhin, S. Smirnova, E. Zilbert, L. Petrova, N. Erokhina, R. V. Halafov, T.O. Svetlichnaya
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Comparition criteria was the results of prenatal and postnatal diagnostics, intraoperative data, postoperative period, complications and outcomes. \nRESULTS: We found predominance of prenatal diagnosis in the second group (48% vs 84%, p = 0,001). The lung-to-head circumference ratio were the same in both groups (0,52 in first, 0,46 in second, p = 0,058). Chance to use thoracoscopic approach in the second group was higer in 5,7 times (48% vs 84%). Postoperative period was easier in the group of right-sided congenital diaphragmatic hernia: artificial ventilation lasted on average 8 days (min 3; max 28) versus 11 (min 4; max 50) days in the first group (p = 0,036). \nHospital stay was significantly lower in the second group 18 days (min 12; max 28), versus 50 days in the first group (min 13; max 64), p = 0,011. 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摘要

背景:右侧先天性膈疝是一种罕见的疾病。诊断、预后和治疗结果通常作为病例集发表。目的:比较以肝为内容的先天性膈疝侧边依赖性的治疗效果。材料与方法:我们对50例新生儿先天性膈疝患者进行回顾性分析。患者分为两组,一组为右侧疝(19例),二组为左侧疝(31例)。各组按性别和体重进行比较。比较标准为产前和产后诊断结果、术中资料、术后时间、并发症和结局。结果:我们发现产前诊断在第二组中占优势(48% vs 84%, p = 0.001)。两组肺头围比相同(第一组为0.52,第二组为0.46,p = 0.058)。第二组采用胸腔镜入路的几率为5,7次(48%对84%)。右侧先天性膈疝组术后时间较短,人工通气时间平均为8天(最短3天;最大28)vs 11(最小4;第一组最多50天(p = 0.036)。第二组患者住院时间明显缩短18天(最短12天;最长28天),而第一组为50天(最短13天;最大64),p = 0,011。右侧疝患者的康复率更高(45% vs 79%,可信区间0,0590,814)。结论:每一种类型的膈疝,包括右侧位置,都需要成为高竞争中心的研究对象。右侧先天性膈疝的预后标准需要进一步的深入研究,这只有在患者集中在同一中心的情况下才有可能。
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The results of treatment of newborns with right-sided and left-sided intrathoracic localization of the liver with diaphragmatic hernia
BACKGROUND: The right-sided congenital diaphragmatic hernia is the rare pathology. Results of diagnostics, prognosis and treatment usally published as a collection of cases. AIM: Comparition of treatment results of congenital diaphragmatic hernia with the liver as its content in dependancy of the side. MATERIALS AND METHODS: We present a retrospective analysis of 50 newborn patients with congenital diaphragmatic hernia. Patiens were divided in two groups, first with right-sided (19 patients), and second with left-sided hernia (31 patients). Groups were compared by gender and weigth. Comparition criteria was the results of prenatal and postnatal diagnostics, intraoperative data, postoperative period, complications and outcomes. RESULTS: We found predominance of prenatal diagnosis in the second group (48% vs 84%, p = 0,001). The lung-to-head circumference ratio were the same in both groups (0,52 in first, 0,46 in second, p = 0,058). Chance to use thoracoscopic approach in the second group was higer in 5,7 times (48% vs 84%). Postoperative period was easier in the group of right-sided congenital diaphragmatic hernia: artificial ventilation lasted on average 8 days (min 3; max 28) versus 11 (min 4; max 50) days in the first group (p = 0,036). Hospital stay was significantly lower in the second group 18 days (min 12; max 28), versus 50 days in the first group (min 13; max 64), p = 0,011. Recovery chance in patients with right-sided hernia was higher (45% vs 79%, confidence interval 0,0590,814). CONCLUSIONS: Every type of diaphragmatic hernia, including right-sided location, need to be the subgect of research of high compitantive center. Prognostic criteria for right-sided congenital diaphragmatic hernia require furter advanced study, wich is possible only in case of concentration of patients in the same center.
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