干扰素α治疗儿童慢性丙型肝炎

Acta paediatrica sinica Pub Date : 1998-06-30 DOI:10.7097/APS.199806.0146

Toomoo Fujisawa, A. Inui, H. Komatsu, Y. Miyagawa, M. Onoue

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引用次数: 1

摘要

我们对53例慢性丙型肝炎患儿进行了3年以上的随访。在血清HCV-RNA滴度较低的患者中，只有3例(6%)出现自发性缓解。我们认为干扰素(IFN)应该应用于所有的慢性丙型肝炎儿童，但那些希望自行缓解的儿童除外。我们评估了干扰素治疗对32名儿童的影响，并调查了可能影响治疗结果的因素。13名儿童(41%)获得完全缓解。IFN耐受性良好。

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Interferon-α Therapy for Children with Chronic Hepatitis C

We followed 53 children with chronic hepatitis C for more than 3 years. Spontaneous remission occurred only 3 (6%) in whom the serum titer of HCV-RNA was low. We considered interferon (IFN) should be adopted in all children with chronic hepatitis C but those who expected to be remitted spontaneously. We evaluated the effect of IFN therapy on 32 children and investigated factors that may influence the outcome of the treatment. A complete response was obtained in 13 children (41%). IFN was well tolerated.

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Acta paediatrica sinica

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