类天疱疮24例临床病理分析

Chisato Nakagawa, Fumihiko Tsushima, J. Sakurai, Atsushi Uesugi, Kiyoshi Sato, Seiichiro Oda, H. Harada
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摘要

类天疱疮是一种以上皮下水疱为特征的自身免疫性大疱性疾病。我们报告了从2007年到2017年到我科就诊的24例类天疱疮患者。其中粘膜类天疱疮21例,大疱性类天疱疮3例。男性5例,女性19例,年龄44 ~ 91岁(中位数:65.5岁)。口腔病变以牙龈(19例)居多,其次为颊黏膜(7例)和上颚(6例)。24例中有18例仅表现为口腔症状。全身性类固醇治疗12例,局部类固醇治疗12例。在12例外用类固醇的病例中,我们联合给药四环素、二氨基二苯基和/或烟酰胺。所有患者的病变都得到了改善,我们继续治疗,并注意复发。我们认为,类天疱疮通常只表现为口腔症状,应与皮肤科医生合作,及时诊断并适当治疗。
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Clinicopathological Study of 24 Cases of Pemphigoid
: Pemphigoid is an autoimmune bullous disease characterized by a subepithelial blister. We report 24 cases of pemphigoid who visited our department from 2007 through 2017. Twenty-one cases were classified as mucous membrane pemphigoid and 3 cases as bullous pemphigoid. They consisted of 5 males and 19 females, 44 to 91 years of age (median: 65.5 years). Lesions in the oral cavity were most frequently located in the gingiva (19 cases), followed by the buccal mucosa (7 cases) and the palate (6 cases). Eighteen of the 24 cases showed only oral manifestations. Treatment with systemic steroid was given to 12 cases, and topical steroid to 12 cases. In 8 of the 12 cases with topical steroid, we co-administered tetracycline, diaminodiphenyl and / or nicotinamide. The lesions of all patients were improved, and we have continued to treat them with attention to relapse. It is considered that a prompt diagnosis should be made and ap-propriate treatment for pemphigoid, which often shows only oral manifestations, should be provided in cooperation with dermatologists.
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