COVID-19的血型和严重程度

B. Ozdemir, L. Ozdemir, Bilge Akgunduz, M. Çelik, Senem Urfali, Ayse Sema Vicdan
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摘要

目的:自血型首次出现以来,其与微生物引起的疾病的关系已经过多年的几项研究进一步调查。A型、B型、AB型和O型血型与冠状病毒的关系一直是许多国家的研究课题。我们的目的是阐明血型和Rh因子与感染COVID-19疾病和疾病严重程度之间是否存在关系。方法:采用回顾性病例对照研究。在2020年3月至2021年2月期间,纳入了1110例患者(538例,572例对照)。疾病严重程度根据患者的治疗地点进行分类:门诊患者被认为是"轻度疾病",在医院病房住院被认为是"中度疾病",在重症监护病房接受治疗被认为是"严重疾病"。结果:A型血447例(40.3%),B型血197例(17.7%),AB型血90例(%8),O型血376例(33.9%)。根据血型,病例组与对照组之间无显著差异。与对照组相比,rh阳性个体出现轻度疾病的几率增加了3.93倍。a型血的女性患严重疾病的几率比轻度疾病高,a型血的女性患严重疾病的几率比其他血型的女性高。结论:A型血的女性比其他血型的女性发病更严重,B型血的女性作为门诊患者存活。本研究可为新型冠状病毒病引起高死亡率大流行与毒力与血型关系的病理生理学研究提供线索。关键词:COVID-19病毒,血型,疾病
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Blood Types and Severity of COVID-19
Aim: Since blood types first appeared, their association with diseases caused by microorganisms has been further investigated with several studies for many years. The bond of blood groups described as A, B, AB, and O with coronavirus has been the research subject in many countries.We aimed to elucidate whether there was a relationship between blood types and Rh factor and contracting COVID-19 disease and disease severity. Methods: The study was designed as a retrospective case-control study. Between March 2020 - February 2021, 1110 patients were included (538 cases, 572 controls). Disease severity was classified according to where patients were treated: those who were outpatients considered as “mild disease”, hospitalized in a hospital ward considered as “moderate disease”, and treated in the intensive care unit were considered as “severe disease”. Results: The number of people with blood type A was 447 (40.3%), blood type B was 197 (17.7%), blood type AB was 90 (%8), and blood type O was 376 (33.9%). There was no significant difference between the case and control groups according to the blood types. A 3.93 times increase of developing mild illness was detected compared to the control group in Rh-positive individuals. The rate of developing a severe disease was higher in females with blood type A than a mild disease, and A blood type caused the disease to be severe compared to other blood groups in females. Conclusion: We concluded that blood type A caused more severe disease than other blood types in females, and females with B blood type survived the disease as outpatients. Our study can shed light on pathophysiological investigation of the relationship between COVID-19 disease causing a pandemic with high mortality and virulence and blood types. Keywords: COVID-19 virus, blood group, disease
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