连续型微流控混合器的紧凑模型

Alexi Bonament, Alexis Prel, J. Sallese, M. Madec, C. Lallement
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摘要

虽然芯片实验室的发展越来越多,但缺乏专用的计算机辅助设计工具成为阻碍大规模工业应用出现的瓶颈。其中一个答案依赖于50年的微电子CAD经验。基于这一事实,并利用这一环境,设计了多领域文库(流体、生物、化学)。其中,开发高效紧凑的微流控器件模型是实现这一设计工具的第一步。本文研究了一种连续式微流控混合器。我们的模型将每一种混合流体的流速和浓度作为输入,并在其输出处返回流经通道的流速和浓度曲线。该模型还取决于一些物理参数(如流体的扩散系数)和混合通道的几何形状。通过与COMSOL Multiphysics有限元仿真的对比,验证了模型的正确性。对几个案例进行了比较。我们证明,该模型给出了一个很好的浓度分布估计,与有限元模拟器相比,误差小于2%。
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Compact Model for Continuous Microfluidic Mixer
While the development of lab-on-chip is increasing, the lack of dedicated computer-aided design tools appears as a bottleneck preventing the emergence of large-scale industrial applications. One of the answer relied on 50 years of CAD experience in microelectronic. Based on this fact, and using this environment, multi-domain libraries (fluidic, biological, chemical) are to be designed. Among other, the development of efficient compact model for microfluidic devices is a first step toward such design tool. This paper deals with a continuous microfluidic mixer. Our model takes as inputs the flow rates and the concentrations of each fluid to mix and returns the flow rate and the concentration profiles across the channel at its output. The model depends also on some physical parameters (e.g. diffusion coefficient of fluids) and mixing channel geometry. The model is validated by comparison with finite-element simulation performed with COMSOL Multiphysics. Comparisons are made on several cases. We demonstrated that the model gives a good estimation of the concentration profile, with an error of less than 2% compared to the finite element simulator.
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