Won Jun Kim, J. Kim, D. Park, C. Lee, Yongsoo Park, Dong Kim, W. Choi, Tae Wha Kim, Y. Ahn
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The prevalence of a thyroid nodule was significantly correlated with age in both women and men (P < 0.001). Multinodularity also increased according to age in both groups. Ninety patients were tested with conventional FNAC and 195 underwent ultrasonography-guided FNAC. The rate of inadequate cytology by ultrasonographic guidance was lower than by freehand methods, and the total rate of malignant cytology per patient was 17.9%. Ultrasonographic characteristics that significantly correlated with histologically-confirmed papillary carcinoma included a solid component, hypoechogenecity, irregular margin, and the presence of microcalcification or macrocalcification. Conclusion: The prevalence of thyroid nodules detected by ultrasonography was 28.3% in healthy women and 16.5% in healthy men population. The prevalence and multinodularity was significantly correlated with age in both groups. It’s useful to examine thyroid by ultrasonography because of detecting more nodules, providing guidance of FNAC, achieving more adequate sampling and not missing small malignant nodules. (J Korean","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"15","resultStr":"{\"title\":\"Prevalence of Thyroid Nodules Detected by Ultrasonography in Adults for Health Check-Ups and Analysis of Fine Needle Aspiration Cytology\",\"authors\":\"Won Jun Kim, J. Kim, D. Park, C. Lee, Yongsoo Park, Dong Kim, W. Choi, Tae Wha Kim, Y. Ahn\",\"doi\":\"10.3803/JKES.2008.23.6.413\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The purpose of this study was to assess the prevalence of thyroid nodules in healthy adults without a history of thyroid disease and the results of fine needle aspiration cytology (FNAC). Methods: We retrospectively studied 4,832 adults (2,427 women, 2,405 men) over the age of 20 who had visited our health care center from January, 2005, to March, 2008. Subjects with previous thyroid disease were excluded. All were screened by thyroid ultrasonography and FNAC was performed on large or potentially malignant nodules. Results: Thyroid nodules were present in 686 women (28.3%) and 396 men ( 16.5%), with a female predominance (odds ratio = 1.47, 95% CI = 1.35~1.60). The prevalence of a thyroid nodule was significantly correlated with age in both women and men (P < 0.001). Multinodularity also increased according to age in both groups. Ninety patients were tested with conventional FNAC and 195 underwent ultrasonography-guided FNAC. The rate of inadequate cytology by ultrasonographic guidance was lower than by freehand methods, and the total rate of malignant cytology per patient was 17.9%. Ultrasonographic characteristics that significantly correlated with histologically-confirmed papillary carcinoma included a solid component, hypoechogenecity, irregular margin, and the presence of microcalcification or macrocalcification. Conclusion: The prevalence of thyroid nodules detected by ultrasonography was 28.3% in healthy women and 16.5% in healthy men population. The prevalence and multinodularity was significantly correlated with age in both groups. It’s useful to examine thyroid by ultrasonography because of detecting more nodules, providing guidance of FNAC, achieving more adequate sampling and not missing small malignant nodules. 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引用次数: 15
摘要
背景:本研究的目的是评估无甲状腺病史的健康成人甲状腺结节的患病率和细针穿刺细胞学检查(FNAC)的结果。方法:我们回顾性研究了2005年1月至2008年3月期间到我们医疗中心就诊的20岁以上的4,832名成年人(2,427名女性,2,405名男性)。排除既往有甲状腺疾病的受试者。所有患者均经甲状腺超声检查,对大结节或潜在恶性结节行FNAC检查。结果:女性686例(28.3%),男性396例(16.5%),女性占优势(优势比= 1.47,95% CI = 1.35~1.60)。男性和女性甲状腺结节的患病率均与年龄显著相关(P < 0.001)。在两组中,多轴性也随着年龄的增长而增加。90例患者行常规FNAC, 195例行超声引导下FNAC。超声引导下的细胞学检查不充分率低于徒手检查,每例患者的恶性细胞学检查率为17.9%。与组织学证实的乳头状癌显著相关的超声特征包括实性成分、低回声、边缘不规则以及微钙化或大钙化的存在。结论:超声检查甲状腺结节检出率在健康女性中为28.3%,在健康男性中为16.5%。两组患者的患病率和多结节性均与年龄显著相关。超声检查甲状腺的优点是能检出更多的结节,为FNAC提供指导,采样更充分,不会遗漏小的恶性结节。(J韩国
Prevalence of Thyroid Nodules Detected by Ultrasonography in Adults for Health Check-Ups and Analysis of Fine Needle Aspiration Cytology
Background: The purpose of this study was to assess the prevalence of thyroid nodules in healthy adults without a history of thyroid disease and the results of fine needle aspiration cytology (FNAC). Methods: We retrospectively studied 4,832 adults (2,427 women, 2,405 men) over the age of 20 who had visited our health care center from January, 2005, to March, 2008. Subjects with previous thyroid disease were excluded. All were screened by thyroid ultrasonography and FNAC was performed on large or potentially malignant nodules. Results: Thyroid nodules were present in 686 women (28.3%) and 396 men ( 16.5%), with a female predominance (odds ratio = 1.47, 95% CI = 1.35~1.60). The prevalence of a thyroid nodule was significantly correlated with age in both women and men (P < 0.001). Multinodularity also increased according to age in both groups. Ninety patients were tested with conventional FNAC and 195 underwent ultrasonography-guided FNAC. The rate of inadequate cytology by ultrasonographic guidance was lower than by freehand methods, and the total rate of malignant cytology per patient was 17.9%. Ultrasonographic characteristics that significantly correlated with histologically-confirmed papillary carcinoma included a solid component, hypoechogenecity, irregular margin, and the presence of microcalcification or macrocalcification. Conclusion: The prevalence of thyroid nodules detected by ultrasonography was 28.3% in healthy women and 16.5% in healthy men population. The prevalence and multinodularity was significantly correlated with age in both groups. It’s useful to examine thyroid by ultrasonography because of detecting more nodules, providing guidance of FNAC, achieving more adequate sampling and not missing small malignant nodules. (J Korean