慢性大剂量氟哌啶醇治疗后对阿波啡和安非他明的行为超敏感。

Psychopharmacology communications Pub Date : 1975-01-01

R C Smith, J M Davis

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摘要

给予慢性氟哌啶醇(5 mg/cc) 2个月的大鼠在慢性氟哌啶醇治疗期间表现出刻板的啃咬行为，在停止氟哌啶醇治疗后，与生理盐水对照组相比，阿哌啶碱或l -安非他明诱导的刻板行为明显增加。长期服用甲磺酸苯托品同时服用氟哌啶醇可降低慢性氟哌啶醇对停药期间药物诱导的刻板行为的影响。

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Behavioral supersensitivity to apomorphine and amphetamine after chronic high dose haloperidol treatment.

Rats administered chronic haloperidol (5 mg/cc) for 2 months exhibited stereotyped gnawing during chronic haloperidol treatment, and after withdrawal from haloperidol, showed significantly greater stereotyped behavior induced by apomorphine or L-amphetamine compared to saline controls. Chronic administration of benztropine mesylate concomitantly with haloperidol reduced the effects of chronic haloperidol on drug induced stereotyped behavior during the withdrawal period.

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Psychopharmacology communications

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