Nesfatin-1 Differences in Cesarean Section Compared to Natural Vaginal Delivery

Abstract Objective: According to previous research, delivery is known as an inflammatory process. Recently discovered Adipokine has been proved with an anti-inflammatory and anti-apoptotic role. Hence, this study aimed to investigate changes of maternal Nesfatin-1 concentrations before and after delivery. Materials and methods: In this nested case control, 166 pregnant women, aged 18-40 and meeting the inclusion criteria, were followed up during 28-32 weeks of gestational age and until after delivery. First mother’s blood serum sample was taken in the third trimester to measure nesfatin-1. Twentythree of these subjects underwent elective CS and were considered as the case group. Then, from the women with vaginal delivery, twenty-two were made homogenous concerning demographic characteristics with case group and selected as the control group. Finally, the second blood sample was taken to measure mother’s serum nesfatin-1 twenty-four hours after delivery. The blood samples were measured by ELISA kit. The data were analyzed by means of SPSS. Results: The results showed that the concentrations of Nesfatin-1 in the third trimester of pregnancy and in the first 24 hours after delivery in the C/S group were [1360.6 ± 2153.4 (Ng/L)], and [1296.8 ± 1925.5 (Ng/L)] and in the NVD group [1483.3 ± 1980.4 (Ng/L)], and [1853.8 ± 2285.7 (Ng/L)] respectively. There was an evident relationship between Nesfatin-1 concentrations before and after delivery in the NVD group (P=0.028). Also, Nesfatin-1 difference before and after delivery in the C/S group had a significant relationship with its difference in the NVD group. (P=0.025). Conclusion: It has been found that the concentrations of serum Nesfatin-1 in the NVD group significantly increased; furthermore, this hormone concentration before and after delivery in NVD were more than C/S group.