Predictors for coronary artery calcium score and differences in its distributions between populations with and without diabetes

Cardiometabolic disease encompasses a variety of metabolic dysfunctions including major public health issues such as insulin resistance, obesity, Type 2 Diabetes (T2DM), and cardiovascular disease (CVD). Inflammation drives the pathogenesis of cardiometabolic disease in clinical, epidemiological, and translational models. T2DM is an established inflammatory condition with many cardiometabolic relationships and is often associated with dyslipidemia and insulin resistance. In this review, psoriasis, a chronic inflammatory disease, is used as a model to explain the relationship between systemic inflammation and the onset and progression of cardiometabolic disease in an effort to better understand T2DM. Future efforts should focus on developing CVD risk scores to reflect the importance of inflammatory states such as T2DM and its contribution to cardiovascular morbidity and mortality.