{"title":"前列环素长期治疗对大鼠胃(胃窦和胃底)粘膜DNA和RNA含量的影响呈剂量依赖性。","authors":"G A Bálint, G Karácsony","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The changes in gastric (antral and fundic) mucosal DNA and RNA contents were investigated in long-term (80 days) treatment of rats with orally administered prostacyclin. Prostacyclin caused a dose-dependent, significant increase of the DNA levels in both parts of the gastric mucosa together with a significant thickening of the fundic mucosa. The observed changes (decrease) of the RNA/DNA ratio in the fundic as well as antral mucosa, are interpreted as a sign of accelerated cell renewal, i.e. hyperplasia.</p>","PeriodicalId":7090,"journal":{"name":"Acta medica Hungarica","volume":"49 1-2","pages":"137-41"},"PeriodicalIF":0.0000,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long-term prostacyclin--treatment acts on the DNA and RNA content of rat gastric (antral and fundic) mucosa dose-dependently.\",\"authors\":\"G A Bálint, G Karácsony\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The changes in gastric (antral and fundic) mucosal DNA and RNA contents were investigated in long-term (80 days) treatment of rats with orally administered prostacyclin. Prostacyclin caused a dose-dependent, significant increase of the DNA levels in both parts of the gastric mucosa together with a significant thickening of the fundic mucosa. The observed changes (decrease) of the RNA/DNA ratio in the fundic as well as antral mucosa, are interpreted as a sign of accelerated cell renewal, i.e. hyperplasia.</p>\",\"PeriodicalId\":7090,\"journal\":{\"name\":\"Acta medica Hungarica\",\"volume\":\"49 1-2\",\"pages\":\"137-41\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta medica Hungarica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta medica Hungarica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Long-term prostacyclin--treatment acts on the DNA and RNA content of rat gastric (antral and fundic) mucosa dose-dependently.
The changes in gastric (antral and fundic) mucosal DNA and RNA contents were investigated in long-term (80 days) treatment of rats with orally administered prostacyclin. Prostacyclin caused a dose-dependent, significant increase of the DNA levels in both parts of the gastric mucosa together with a significant thickening of the fundic mucosa. The observed changes (decrease) of the RNA/DNA ratio in the fundic as well as antral mucosa, are interpreted as a sign of accelerated cell renewal, i.e. hyperplasia.
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