Inyección intraarticular única de ácido hialurónico en la gonartrosis sintomática: estudio comparativo de la eficacia de dos presentaciones y cambio de protocolo.

Introduction: Vicosupplementation with hyaluronic acid in knee osteoarthritis has proven to be a safe and effective treatment. Its effectiveness is maintained for at least 6 months. Few studies have compared the efficacy of two single injection products at 12 months. Objective: To evaluate the efficacy results in patients infiltrated with two single injection hyaluronic acid : Hyalone® (H) and Adant One® (A), at 12 months. Material and methods: A retrospective observational study has been designed on a cohort of patients with knee osteoarthritis. They were treated by intra-articular knee viscosupplementation with two types of single injection hyaluronic acid. Its efficacy was evaluated according to the WOMAC scale and the VAS at 6 and 12 months. Results: 86 patients were treated with single doses of A and 67 with H. A significant improvement was found in the WOMAC assessment at 6 months with A (p = 0.035), while at 12 months the result no longer showed statistical significance (p = 0.184). With H at 12 months the improvement in the WOMAC values continued to be favorable (p = 0.039). Regarding pain control, an improvement in the VAS was observed, which was significant only in the case of H at 12 months (p = 0.020). Conclusions: A single H injection at 12 months was more effective for pain control and improved functionality in patients with knee osteoarthritis compared to A. It is possible to make viscosupplementation protocols for knee osteoarthritis with hyaluronic acid at annual intervals using H.