阿米卡星在γ辐照小鼠体内的药代动力学。

S Lipski, A Gasiewski, J Chaś
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引用次数: 0

摘要

采用TDX系统(Abbott),基于荧光偏振免疫法检测9 Gy γ射线照射后24 h小鼠血清中阿米卡星的浓度。根据所得数据计算药物处置(分布+消除)的药代动力学参数。在辐照小鼠中观察到阿米卡星处置的快、慢两期。相反,在未辐照的小鼠中,只观察到药物处置的一个快速期。讨论了抗生素的配置参数与放疗后肾小管营养不良和血管变化的关系。
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Pharmacokinetics of amikacin in gamma-irradiated mice.

Concentrations of amikacin in sera, investigated 24 h after irradiation with 9 Gy gamma-rays of mice, were monitored using TDX system (Abbott), based on the fluorescence polarization immunoassay. Pharmacokinetic parameters of disposition (distribution + elimination) of the drug were calculated from the obtained data. In irradiated mice fast and slow phases of amikacin disposition were noted. In contrary, in the non irradiated mice only one-fast phase of the drug disposition was observed. The dependence of the disposition parameters of the antibiotic to the postirradiation tubular dystrophia and vascular changes was discussed.

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