使用混合方法的微阵列数据的双向聚类

R. Malutan, B. Belean, P. G. Vilda, M. Borda
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引用次数: 3

摘要

微阵列技术相当强大,因为它允许一次测试数千个基因,但这产生了一组压倒性的数据文件,其中包含大量数据,很难预处理,分离,分类和关联,以提取有趣的结论。需要基于信息论的现代机器学习、数据挖掘和聚类技术来读取和解释隐藏在这些大数据集中的信息内容。独立成分分析方法可用于校正受损坏过程影响的数据或过滤不正确的数据,然后聚类方法可对相似基因进行分组或对样本进行分类。本文采用一种混合方法对修正后的微阵列数据进行双向无监督聚类。
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Two way clustering of microarray data using a hybrid approach
The Microarray technique is rather powerful, as it allows to test up thousands of genes at a time, but this produces an overwhelming set of data files containing huge amounts of data, which is quite difficult to pre-process, separate, classify and correlate for interesting conclusions to be extracted. Modern machine learning, data mining and clustering techniques based on information theory, are needed to read and interpret the information contents buried in those large data sets. Independent Component Analysis method can be used to correct the data affected by corruption processes or to filter the uncorrectable one and then clustering methods can group similar genes or classify samples. In this paper a hybrid approach is used to obtain a two way unsupervised clustering for a corrected microarray data.
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