肾小球滤过率(GFR)的临床肾脏病学和药理学研究进展

H. Bando, Y. Kato, Y. Kato
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引用次数: 0

摘要

近年来,慢性肾病(CKD)、糖尿病肾病(DKD)、肾小球滤过率(GFR)等相关问题已成为人们关注的焦点。估计GFR (eGFR)通常通过血清肌酐和年龄通过体表面积(BSA)校正来计算。相反,Cockcroft-Gault公式是另一种不被BSA修正的方法。当患者体格明显变大或变小时,BSA矫正可显著改变eGFR值。基于日本多机构协作队列研究(J-MICC)的数据,探讨影响肾功能的各种因素。结果表明,男性的问题解决程度与eGFR呈负相关。
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Recent Trends for Clinical Nephrology and Pharmacology Concerning Glomerular Filtration Rate (GFR)
Recently, chronic kidney disease (CKD), diabetic kidney disease (DKD), glomerular filtration rate (GFR) and related matters have been in focus. Estimated GFR (eGFR) has been usually calculated by serum creatinine and age corrected by body surface area (BSA). In contrast, Cockcroft-Gault formula is another way that is not corrected by BSA. When the patient's physique is significantly larger or smaller, BSA correction may remarkably change the value of eGFR. Based on the data of Japan Multi-institutional Collaborative Cohort (J-MICC) study, various factors influencing renal function were investigated. As a result, problem solving degree in men revealed inverse relationship with eGFR.
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