磷脂酶C同工酶的调控

Progress in growth factor research Pub Date : 1992-01-01 DOI:10.1016/0955-2235(92)90025-D

Gwenith Jones, Graham Carpenter

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引用次数: 14

摘要

磷脂酰肌醇二磷酸水解是对包括生长因子在内的许多激素的直接反应。磷脂酰肌醇二磷酸水解是由磷脂酰肌醇特异性磷脂酶C催化的，许多磷脂酶C同工酶已被鉴定。不同的同工酶被不同的受体激活。本文将对磷脂酶C的同工酶进行综述，并对生长因子调控磷脂酶C活性的机制进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Regulation of phospholipase C isozymes

Phosphatidylinositol bisphosphate hydrolysis is an immediate response to many hormones, including growth factors. The hydrolysis of phosphatidylinositol bisphosphate is catalyzed by phosphatidylinositol-specific phospholipase C. A number of phospholipase C isozymes have been identified. Different isozymes are activated by different receptor classes. This review will summarize the different isozymes of phospholipase C, and the current knowledge of the mechanisms by which phospholipase C acitivity is modulated by growth factors.

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