大尺寸支架治疗新生长冠状动脉病变的安全性:随访1.5年的结果,单中心经验

A. Islam, S. Munwar, A. H. Bhuiyan, A. Reza, S. Talukder, T. Ahmed, Nighat Islam, A. B. Siddique, Intekhab Yousuf, Z. Rahman, Alam
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摘要

背景:经皮冠状动脉介入治疗(PCI)采用长单支架或重叠多支架治疗长病变,由于金属负担增加以及冠脉介入治疗增加住院费用,可能会增加ISR的发生率。因此,我们研究的主要目的是评估单个更大尺寸支架治疗长病变的长期安全性,并通过冠状动脉造影和/或临床评估在我们的OPD进行随访。方法:选取2014年至2017年10月中旬在我中心行PCI术、病变时间较长、支架使用时间大于38mm的患者进行分析。本研究共纳入255例患者(男性213例,女性42例),接受择期PCI和CAG随访,平均随访时间为1.5年。255例患者共放置了267个支架,其中一些患者患有双血管疾病。男性和女性的平均年龄分别为55.56岁。冠心病(CAD)相关危险因素为血脂异常、高血压、糖尿病、冠心病FH阳性和吸烟(均为男性)、CKD、甲状腺功能减退。结果:研究组中;高血压192例(75.3%);血脂异常189例(74.1%),糖尿病126例(49.4%),FH 74阳性(29.4%),CKD 8(3.1%),甲状腺功能减退2(0.8%)和104例(40.8%)均为男性吸烟者。常见支架区域为LAD 126(49.4%), RCA 115(45.1%), LCX 24(9.4%)。总患者中,单血管支架236例(92.5%),DVD 19例(7.5%)。共部署支架267个,其中48mm共159个(59.6%);40 mm血管中有61根(22.8%),38 mm血管中有47根(17.6%)。在平均1.5年的随访期间,所有支架区域保持通畅,无任何残留狭窄。结论:我们的结论是,在平均随访时间为1.5年的情况下,使用单个更大尺寸的支架治疗冠状动脉长病变是安全的,没有任何残留狭窄。因此,为了减少复发性ISR的机会,再次住院并降低医院费用。孟加拉国心脏杂志2018;33(2): 106-111
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Safety of Longer Size Stent in Treating De-Novo Long Coronary Lesion: Outcome at 1.5 Years Follow-Up, A Single Center Experience
Background: Percutaneous coronary intervention (PCI) of long lesions by long single stent or overlapping multiple stent might have higher incidences of ISR due to increased metal burden as well as coronary intervention increase cost of hospital stay. Therefore, our primary aim of our study was to evaluate the longterm safety of treating long lesion by a single longer size stent and its follow-up by coronary angiogram and or clinical evaluation at our OPD. Methods: patient who had gone through PCI from the year 2014 to mid Oct 2017 at our center, had longer lesion and were treated by more than 38mmstent were selected and analyzed. Total 255(Male 213: Female 42) patients were enrolled in this study, underwent elective PCI and follow up CAG at on average 1.5 yrs. Total 267 stents were deployed in 255 patients, in some of the patient had double vessel disease to treat. Mean age for both male: female was(55 :56) yrs. Associated Coronary artery disease (CAD) risk factors were Dyslipidemia, Hypertension, Diabetes Mellitus, Positive FH for CAD and Smoking (all male), CKD, Hypothyroidism. Results: Among the study group; 192 (75.3 %) were hypertensive; 189(74.1%) were Dyslipidemic, 126(49.4%) patients were Diabetic, positive FH 74(29.4 %), CKD 8 (3.1%), Hypothyroidism 2 (0.8%) and 104(40.8%) were all male smoker. Common stented territory was, LAD 126(49.4%), RCA 115(45.1%), and LCX 24(9.4%).Among the total patient population, Single vessel stented were 236 (92.5%) and DVD 19 (7.5%). Total 267 stents were deployed, among them 48mm were in total 159 (59.6%); among 40 mm were stented in 61(22.8%) and 38 mm in 47(17.6%) vessels. At an average follow-up period of 1.5 years, all stented territory remain patent without any residual stenosis. Conclusion: We conclude that treating de-novo coronary long lesion by a single longer size stent is safe without any residual stenosis at an average followup period of 1.5 yrs. Thus, to reduce chances of recurrent ISR, hospital re-admission and reduce hospital cost as well. Bangladesh Heart Journal 2018; 33(2) : 106-111
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