CD64染色在皮肤纤维瘤中:一个敏感的标记物,提出了该肿瘤细胞分化谱系的问题

M. Llamas‐Velasco, T. Mentzel, Enrique Ovejero-Merino, M. Fernández-Figueras, H. Kutzner
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引用次数: 1

摘要

皮肤纤维瘤(DF)是一种真皮间充质肿瘤,但其确切的分化谱系仍不确定。有一种祖细胞可以分化为成纤维细胞、肌成纤维细胞或纤维组织细胞。一些作者也提出了单核细胞-组织细胞起源的可能性。我们用CD64、CD34、CD14、CD163和CD68对47个连续的皮肤纤维瘤进行染色,以测试哪种标记物更可靠地用于诊断并深入了解其组织发生。35例全免疫组化染色均为CD64阳性,多呈强弥漫型。在所有其他染色中,CD14在77%的病变中呈强阳性,CD163在20%的病变中呈强阳性。CD68染色强烈且弥漫性仅占20%。所有病变均为CD34阴性,但其中2个病变呈斑片状、弱染色。CD14、CD68、CD163和CD64等巨噬细胞/单核细胞/组织细胞谱系标记物对DFs进行免疫组化染色。这一发现支持一个活跃的促炎未成熟单核细胞谱系作为更合适的起源的DF。CD64似乎比其他标志物更敏感,以确认诊断。
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CD64 Staining in Dermatofibroma: A Sensitive Marker Raising the Question of the Cell Differentiation Lineage of This Neoplasm
Dermatofibroma (DF) is a mesenchymal tumor of the dermis, but its exact differentiation lineage is still uncertain. A progenitor cell that may be able to differentiate into fibroblastic, myofibroblastic, or fibrohistiocytic cells has been hypothesized. Some authors have also proposed the possibility of a monocytic-histiocytic origin. We stained 47 consecutive dermatofibromas with CD64, CD34, CD14, CD163, and CD68 to test which marker is more reliable for the diagnosis and to gain insight into their histogenesis. From the 35 cases stained with the whole immunohistochemical panel, all were positive for CD64, mostly showing a strong and diffuse pattern. Regarding all the other staining, CD14 was strongly positive in 77% of the lesions and CD163 in 20%. The CD68 stain was intense and diffuse only in 20% of the cases. All lesions were negative for CD34, but two of them showed patchy and weak staining. DFs were immunohistochemically stained positively with a set of macrophage/monocyte/histiocyte lineage markers such as CD14, CD68, CD163, and CD64. This finding favors an active pro-inflammatory immature monocyte-lineage cell as the more suitable origin for DF. CD64 seems to be more sensitive than other markers to confirm the diagnosis.
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