1例64岁女性冠状病毒感染时诊断为浆细胞白血病的临床观察

Yu. E. Ryabukhina, O. L. Timofeeva, P. A. Zeynalova, F. М. Abbasbeyli, M. V. Antonets, V. E. Gruzdev, M. A. Anisimov, A. A. Akhobekov, N. Kupryshina
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摘要

浆细胞白血病(PCL)是一种罕见的恶性浆细胞肿瘤,临床进展积极,治疗反应低,预后不良。合并新型冠状病毒感染(COVID-19)及其并发症显著恶化PCL患者预后。目前,PCL的治疗方法尚未最终确定,并采用了多发性骨髓瘤的治疗方案。在PCL中,最常见的临床症状是肾衰竭和高钙血症,这在多发性骨髓瘤中经常观察到。因此,在多发性骨髓瘤中使用已证实有效的蛋白酶体抑制剂(硼替佐米)是合理的。报告1例64岁女性新型冠状病毒感染(COVID-19)因身体状况不佳住院的临床观察。住院期间怀疑PCL首发,经生命指征确诊后,尽快开始抗肿瘤药物治疗,取得积极效果。
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Clinical observation of a 64-year-old female patient with plasma cell leukemia diagnosed during coronavirus infection COVID-19
Plasma cell leukemia (PCL) is a rare malignant plasma cell neoplasm with aggressive clinical progression, minimal response to therapy and unfavorable prognosis. Concomitant new coronavirus infection COVID-19 and its complications significantly worsen prognosis in patients with PCL. Currently, approaches to PCL therapy are not finalized, and regimens developed for multiple myeloma are used. In PCL, the most common clinical symptoms are renal failure and hypercalcinemia which are frequently observed in multiple myeloma. Therefore, use of proteasome inhibitor (bortezomib) with proven effectiveness in multiple myeloma, is justified. A clinical observation of a 64-year-old female patient who was hospitalized in poor physical condition with the new coronavirus infection COVID-19 is presented. During hospitalization, debut of PCL was suspected, and as soon as possible after diagnosis confirmation using vital indications, antitumor drug therapy was started with positive effect. 
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