{"title":"全氟化学物质在大鼠肝脏和脾脏中的滞留。","authors":"K C Lowe, P K Bentley","doi":"10.3109/10731199209119758","DOIUrl":null,"url":null,"abstract":"<p><p>The uptake and retention of perfluorochemicals (PFCs) into rat liver and spleen have been measured for up to 28 d following injection of either the commercial PFC emulsion, Fluosol, or a novel perfluorodecalin (FDC)-based emulsion. Both quantitative and qualitative differences in the retention of individual PFCs were observed, depending on composition of emulsion administered. Nevertheless, uptake of PFCs into the spleen was consistently greater than into the liver, irrespective of formulation injected.</p>","PeriodicalId":77039,"journal":{"name":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","volume":"20 2-4","pages":"1029-31"},"PeriodicalIF":0.0000,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199209119758","citationCount":"7","resultStr":"{\"title\":\"Retention of perfluorochemicals in rat liver and spleen.\",\"authors\":\"K C Lowe, P K Bentley\",\"doi\":\"10.3109/10731199209119758\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The uptake and retention of perfluorochemicals (PFCs) into rat liver and spleen have been measured for up to 28 d following injection of either the commercial PFC emulsion, Fluosol, or a novel perfluorodecalin (FDC)-based emulsion. Both quantitative and qualitative differences in the retention of individual PFCs were observed, depending on composition of emulsion administered. Nevertheless, uptake of PFCs into the spleen was consistently greater than into the liver, irrespective of formulation injected.</p>\",\"PeriodicalId\":77039,\"journal\":{\"name\":\"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology\",\"volume\":\"20 2-4\",\"pages\":\"1029-31\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3109/10731199209119758\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3109/10731199209119758\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/10731199209119758","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Retention of perfluorochemicals in rat liver and spleen.
The uptake and retention of perfluorochemicals (PFCs) into rat liver and spleen have been measured for up to 28 d following injection of either the commercial PFC emulsion, Fluosol, or a novel perfluorodecalin (FDC)-based emulsion. Both quantitative and qualitative differences in the retention of individual PFCs were observed, depending on composition of emulsion administered. Nevertheless, uptake of PFCs into the spleen was consistently greater than into the liver, irrespective of formulation injected.
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