人类基因组计划的颠覆性反思

Alexander B. Rosenberg
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引用次数: 2

摘要

通过发展一个精心设计的寓言,本文试图表明,人类基因组计划宣传的目标是对构成人类基因组的整个30亿碱基对核酸分子的初级序列进行测序,这在科学上是没有意义的。这就提出了这样的问题:该项目的真正目的是什么?为什么分子生物界选择提供初级序列作为资助目标,而确定遗传物质的重要功能子区域既有用得多,又可以独立实现。
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Subversive Reflections on the Human Genome Project
By developing an elaborate allegory, this paper attempts to show that the advertised aim of the Human Genome project, to sequence the entire 3 billion base pair primary sequence of the nucleic acid molecules that constitute the human genome, does not make scientific sense. This raises the questions of what the real aim of the project could be, and why the molecular biological community has chosen to offer the primary sequence as the objective to be funded, when identifying functionally important sub-regions of the genetic material is both far more useful and independently attainable an aim.
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