EPSAC versus PID control of neuromuscular blockade

The paper deals with the implementation of two controllers for the administration of neuromuscular blockade agents in general anaesthesia: Proportional-Integral-Derivative (PID) and Extended Prediction Self-Adaptive Control (EPSAC). Predictive control requires prior knowledge of system dynamics, therefore a mathematical model is required. A Wiener model has been initially identified, using real data recorded during surgical interventions. The controllers were applied to 8 simulated patients and performance was analyzed and discussed for reference tracking and inter-patient variability.