初孕36-37周慢性髓性白血病、贫血和血小板减少症患者的治疗:1例报告

M. Yusuf, R. Hartono
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摘要

慢性骨髓性白血病(CML)是一种由造血干细胞紊乱引起的癌症。CML本身很少发生在分娩中的妇女,在这种情况下的高级手术已经成为医生,特别是麻醉师的特殊挑战。这限制了标准麻醉指南的发展,因此在本病例中,我们描述了在全身麻醉下剖宫产术中妊娠CML的发生率。第一位怀孕患者怀孕36周;患者于26-28周时首次诊断为慢性粒细胞白血病(Chronic myelelogenous leukemia, CML),当时患者主诉经常头晕、腹痛、乏力,随后患者主诉牙龈出血,目前患者主诉流鼻血。结论:慢性髓性白血病(CML)(疑似非典型CML)伴营养缺乏。我们使用芬太尼100微克,异丙酚80毫克,罗库溴铵50毫克的方案进行全身麻醉技术快速顺序插管。患者入住ICU 2天后转重症监护室,静脉给予扑热息痛1g 4次,头孢唑林1g 2次/ d,兰索拉唑30 mg 1次/ d,氨甲环酸1gr 3次/ d,芬太尼持续15 mcg / h。ICU的血流动力学患者情况稳定。术后第2天,患者转至高护病房,术后第3天患者血流动力学稳定,转至普通病房。
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Management of Patient Primigravida 36-37 Weeks with Chronic Myeloid Leukemia, Anemia, and Thrombocytopenia: A Case Report
Chronic myelogenous leukemia (CML) is a type of cancer caused by a disturbance in the hematopoietic stem cells. CML itself rarely occur on women who are in labor and an advanced procedure in this event has become a special challenge for medics, especially an anesthesiologist. This limits the development of standard anesthesia guidelines, so in this case we describe the incidence of CML in pregnancies performed by Cesarean section with general anesthesia.The first pregnant patient was 36 weeks pregnant; the patient was first diagnosed with Chronic myelogenous leukemia (CML) at the age of 26-28 weeks, at that time the patient complained of frequent dizziness, abdominal pain and weakness, then the patient complained of bleeding gums, and currently the patient complained of nosebleeds. The Bone Marrow shows Conclusion an accelerated phase chronic myeloid leukemia (CML) (suspected atypical CML) with nutritional deficiency. We perform General Anesthesia technique Rapid Sequence Intubation with Regimen Fentanyl 100 mcg, Propofol 80 mg and Rocuronium 50 mg.The patient was admitted to the ICU for 2 days before transferring to intensive care and the patient received intravenous paracetamol 1 gram four times, cefazolin 1 gram twice a day, lansoprazole 30 mg once a day, tranexamic acid 1gr three times a day, and 15 mcg per hour fentanyl contionously. Hemodynamic patients in the ICU are in a stable condition. On the second postoperative day of care, the patient was transferred to the High care ward, then at the third postoperative day the patient's hemodynamics was stable and the patient was transferred to a normal room.
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