在SHR中,钙对中枢血管紧张素II的抑制作用较小。

H Itoh, K Takeda, M Tanaka, M Hirata, S Kawasaki, J Hayashi, M Oguro, S Sasaki, M Nakagawa
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引用次数: 3

摘要

为了确定钙是否改变中枢心血管调节,我们记录了清醒Wistar大鼠对脑室内(ICV)注射钙的心血管反应。钙注射持续产生平均静脉压和心率的剂量依赖性降低。钙通道阻滞剂地尔硫卓预处理可减弱心血管对钙的反应。血浆去甲肾上腺素的下降表明交感神经抑制对钙抑制血管的作用。先前的钙注射降低了icv注射血管紧张素II的降压反应。这些发现提示在中枢神经系统中钙和血管紧张素II之间存在药理学相互作用。自发性高血压大鼠(SHR)对钙的心血管反应大于Wistar Kyoto大鼠(WKY)。相比之下,钙仅在WKY中降低了血管紧张素II的降压反应,而在SHR中没有。由于钙和血管紧张素II之间的中心相互作用在SHR中有所不同,我们的研究结果表明这种差异可能与SHR中高血压的维持有关。
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Calcium suppresses central angiotensin II pressor response less in SHR.

To determine whether calcium alters central cardiovascular regulation, cardiovascular responses to intracerebroventricular (ICV) injection of calcium were recorded in conscious Wistar rats. Calcium injection consistently produced dose-dependent decreases in mean parterial pressure and heart rate. Pretreatment with a calcium channel blocker, diltiazem, attenuated cardiovascular responses to calcium. Decreases in plasma norepinephrine indicated the contribution of sympatho-inhibition to vasodepression by calcium. Preceding calcium injection reduced pressor responses to ICV-injected angiotensin II. These findings suggest that there is a pharmacological interaction between calcium and angiotensin II in the central nervous system. In spontaneously hypertensive rats (SHR), cardiovascular responses to calcium was larger than Wistar Kyoto rats (WKY). By contrast, calcium reduced pressor responses to angiotensin II only in WKY but not in SHR. Because the central interaction between calcium and angiotensin II has been different in SHR, our results imply that this difference may be related to the maintenance of high blood pressure in SHR.

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