S.P. Hume , A.A. Lammertsma , C.J. Bench , V.W. Pike , C. Pascali , J.E. Cremer , R.J. Dolan
{"title":"S-[11C]西酞普兰作为放射性配体在体内标记5-羟色胺摄取位点的评价","authors":"S.P. Hume , A.A. Lammertsma , C.J. Bench , V.W. Pike , C. Pascali , J.E. Cremer , R.J. Dolan","doi":"10.1016/0883-2897(92)90171-T","DOIUrl":null,"url":null,"abstract":"<div><p>The biologically active <em>S</em>-enantiomer of [<em>N</em>-methyl-<sup>11</sup>C]citalopram was evaluated as a radioligand for <em>in vivo</em> labelling of the 5-hydroxytryptamine uptake site in brain, using <em>ex vivo</em> tissue counting in rats and positron emission tomography in man. In rats, the maximal signal for total versus non-specific binding was approx. 2 at 60–120 min after radioligand injection. Subsequent studies in man failed to identify a specific signal over a 90 min scanning period, due to prolonged retention of non-specific label.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 8","pages":"Pages 851-855"},"PeriodicalIF":0.0000,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90171-T","citationCount":"21","resultStr":"{\"title\":\"Evaluation of S-[11C]citalopram as a radioligand for in vivo labelling of 5-hydroxytryptamine uptake sites\",\"authors\":\"S.P. Hume , A.A. Lammertsma , C.J. Bench , V.W. Pike , C. Pascali , J.E. Cremer , R.J. Dolan\",\"doi\":\"10.1016/0883-2897(92)90171-T\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The biologically active <em>S</em>-enantiomer of [<em>N</em>-methyl-<sup>11</sup>C]citalopram was evaluated as a radioligand for <em>in vivo</em> labelling of the 5-hydroxytryptamine uptake site in brain, using <em>ex vivo</em> tissue counting in rats and positron emission tomography in man. In rats, the maximal signal for total versus non-specific binding was approx. 2 at 60–120 min after radioligand injection. Subsequent studies in man failed to identify a specific signal over a 90 min scanning period, due to prolonged retention of non-specific label.</p></div>\",\"PeriodicalId\":14328,\"journal\":{\"name\":\"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology\",\"volume\":\"19 8\",\"pages\":\"Pages 851-855\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0883-2897(92)90171-T\",\"citationCount\":\"21\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/088328979290171T\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/088328979290171T","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evaluation of S-[11C]citalopram as a radioligand for in vivo labelling of 5-hydroxytryptamine uptake sites
The biologically active S-enantiomer of [N-methyl-11C]citalopram was evaluated as a radioligand for in vivo labelling of the 5-hydroxytryptamine uptake site in brain, using ex vivo tissue counting in rats and positron emission tomography in man. In rats, the maximal signal for total versus non-specific binding was approx. 2 at 60–120 min after radioligand injection. Subsequent studies in man failed to identify a specific signal over a 90 min scanning period, due to prolonged retention of non-specific label.
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