{"title":"有效浓度在解释溶血数据中的作用。","authors":"G H Ward, S H Yalkowsky","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Problems inherent in traditional methods of determining the hemolytic activity of parenteral compounds are discussed. Data taken from a study which closely models the conditions present for an intravenous injection are re-examined. An equation is given which combines several variables into a single parameter, the effective concentration. A strong relationship is found between the effective concentration of the compound of interest and the hemolysis produced.</p>","PeriodicalId":16667,"journal":{"name":"Journal of parenteral science and technology : a publication of the Parenteral Drug Association","volume":"46 5","pages":"161-2"},"PeriodicalIF":0.0000,"publicationDate":"1992-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of the effective concentration in interpreting hemolysis data.\",\"authors\":\"G H Ward, S H Yalkowsky\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Problems inherent in traditional methods of determining the hemolytic activity of parenteral compounds are discussed. Data taken from a study which closely models the conditions present for an intravenous injection are re-examined. An equation is given which combines several variables into a single parameter, the effective concentration. A strong relationship is found between the effective concentration of the compound of interest and the hemolysis produced.</p>\",\"PeriodicalId\":16667,\"journal\":{\"name\":\"Journal of parenteral science and technology : a publication of the Parenteral Drug Association\",\"volume\":\"46 5\",\"pages\":\"161-2\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of parenteral science and technology : a publication of the Parenteral Drug Association\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of parenteral science and technology : a publication of the Parenteral Drug Association","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The role of the effective concentration in interpreting hemolysis data.
Problems inherent in traditional methods of determining the hemolytic activity of parenteral compounds are discussed. Data taken from a study which closely models the conditions present for an intravenous injection are re-examined. An equation is given which combines several variables into a single parameter, the effective concentration. A strong relationship is found between the effective concentration of the compound of interest and the hemolysis produced.
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