Flurbiprofen Axetil For Prevention Of Propofol Injection Pain In Adult --- A Systematic Review

Abstract: Purpose: This review evaluates the efficacy of furbiprofen axetil for preventing pain on injection of propofol. Methods: The following databases were searched including Medline (1966-2009), EMBASE (1990-2009), CINAHL, The Cochrane Central Register of Controlled Trials, and Scopus for randomized controlled trials assessing flurbiprofen axetil intervention for propofol induced injection pain. Trials were included where adults were randomized to receive flurbiprofen axetil or control including placebo, no treatment, or other pharmacologic intervention. Data were abstracted on the incidence and severity of pain at the propofol injection site. Adverse effects related to flurbiprofen axetil were also extracted. Combined data were analyzed using a random effects model. Results: Ten clinical trials were included. The incidence of patients without pain was significantly higher in flurbiprofen axetil group compared with no treatment control or placebo control (Risk Ratio [RR]: 3.46, 95% CI: 2.18, 5.49) with number needed to treat (NNT) of 2.6. The NNT for the incidence of patients without pain was 2.5, 2.1 and 5.0 in flurbiprofen axetil 50 mg pretreatment without venous occlusion, flurbirofen axetil 50 mg preceded by venous occlusion, and flubiprofen axetil 25mg preceded by venous occlusion group, respectively. The incidence of moderate or severe pain was also significantly lower in patients receiving flubiprofen axetil intervention compared with no treatment control (RR: 0.41, 95% CI: 0.31, 0.56).Conclusion: Flurbiprofen axetil reduces the incidence and severity of propofol induced injection pain. Purpose: This review evaluates the efficacy of furbiprofen axetil for preventing pain on injection of propofol. Methods: The following databases were searched including Medline (1966-2009), EMBASE (1990-2009), CINAHL, The Cochrane Central Register of Controlled Trials, and Scopus for randomized controlled trials assessing flurbiprofen axetil intervention for propofol induced injection pain. Trials were included where adults were randomized to receive flurbiprofen axetil or control including placebo, no treatment, or other pharmacologic intervention. Data were abstracted on the incidence and severity of pain at the propofol injection site. Adverse effects related to flurbiprofen axetil were also extracted. Combined data were analyzed using a random effects model. Results: Ten clinical trials were included. The incidence of patients without pain was significantly higher in flurbiprofen axetil group compared with no treatment control or placebo control (Risk Ratio [RR]: 3.46, 95% CI: 2.18, 5.49) with number needed to treat (NNT) of 2.6. The NNT for the incidence of patients without pain was 2.5, 2.1 and 5.0 in flurbiprofen axetil 50 mg pretreatment without venous occlusion, flurbirofen axetil 50 mg preceded by venous occlusion, and flubiprofen axetil 25mg preceded by venous occlusion group, respectively. The incidence of moderate or severe pain was also significantly lower in patients receiving flubiprofen axetil intervention compared with no treatment control (RR: 0.41, 95% CI: 0.31, 0.56).Conclusion: Flurbiprofen axetil reduces the incidence and severity of propofol induced injection pain.