研究碳纳米吸附剂在实验性肾功能衰竭模型中的效果

Ablaikhanova Nt, Tusupbekova Ga, Beissova A, Ussipbek B, Mukhitdinov Am, Yessenbekova A, Balmaganbet Za, Ursheeva B, Atanbayeva Gk, Ye Zb
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摘要

本文研究了纳米吸收剂在实验性肾功能衰竭模型中纠正肾脏功能状态违规的有效性。获得的数据为进一步研究纳米肠吸附剂作为一种新的纳米肠吸附剂和药物递送手段在实际医学中使用的可能性提供了机会。研究分为以下几组:第一组为对照组;2组:急性肾功能衰竭实验模型;3组-纳米肠吸收剂以650 mg/kg / d的剂量灌胃急性肾功能衰竭动物。试验3、14、21 d,对各组进行生化指标分析。在研究过程中,纳米吸附剂灌胃并没有降低实验性尿毒症的动力学,但在3天内降低了平均质量分子水平的浓度,在肾功能衰竭形成后的14天内,根据尿素和肌酐的读数,它也没有改善肾脏的功能状态,但根据EI数据,它在统计学上减少了内源性中毒。在肾衰竭形成后,每天以650 mg/kg的剂量灌胃纳米肠吸收剂,可在21天后降低尿毒症(尿素、肌酐水平)和内源性中毒(平均质量分子水平)。研究发现,日剂量为650 mg/kg的纳米吸收剂对动物的一些生化指标有最佳改善。
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Studying the efficiency of carbon nano enterosorbents in the model of experimental renal failure
The current article examines the effectiveness of nanoenterosorbent to correct violations of the functional state of the kidneys in the experimental renal failure model. The obtained data open up opportunities for further research aimed at studying the possibility of using nanoenterosorbent in practical medicine as a new nanoenterosorbent and a means of drug delivery. The study was conducted in the following groups of animals: group 1 - control group; group 2 - an experimental model of acute renal failure; group 3 - nanoenterosorbent was administered intragastrically at a dose of 650 mg/kg per day to animals with acute renal failure. During the experiment for 3, 14 and 21 days, an analysis of biochemical parameters was obtained from each group. During the investigation, intragastric administration of the nanoenterosorbent did not reduce the dynamics of experimental uremia but reduced the concentration of level of molecular of average mass within 3 days, it also did not improve the functional state of the kidneys according to the readings of urea and creatinine for 14 days after the formation of renal failure, however, it statistically reduced endogenous intoxication according to EI data. Daily intragastric administration of nanoenterosorbent at a dose of 650 mg/kg after the formation of renal failure reduced uremia (urea, creatinine levels) and endogenous intoxication (level of molecular of average mass) after 21 days. Based on the studies, it was found that animals that received nanoenterosorbent at a daily dose of 650 mg/kg, show an optimal improvement in some biochemical parameters.
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