来自动物模型的诱导多能干细胞:在转化研究中的应用

Laís Vicari de Figueiredo Pessôa, Naira Caroline Godoy Pieri, K. Recchia, Fabiana Fernandes Bressan
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引用次数: 1

摘要

在人类历史上,关于人体、健康和新生物医学技术的知识获取在某种程度上贯穿于一些动物模型中。长期以来,老鼠模型一直被主要用作角色模型;然而,它在转化结果方面的可行性受到严重阻碍,特别是在临床前和临床研究方面。在这里,我们的目标是讨论如何从非人类灵长类动物,猪和狗中产生的诱导多能干细胞,这些都是众所周知的足够大的生物医学模型,与基因编辑工具相关或不相关,可以用作体内或体外转化研究的模型,特别是再生医学,药物筛选和干细胞治疗。
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Induced Pluripotent Stem Cells from Animal Models: Applications on Translational Research
Over the history of humankind, knowledge acquisition regarding the human body, health, and the development of new biomedical techniques have run through some animal model at some level. The mouse model has been primarily used as the role model for a long time; however, it is severely hampered regarding its feasibility for translational outcomes, in particular, to preclinical and clinical studies. Herein we aim to discuss how induced pluripotent stem cells generated from non-human primates, pigs and dogs, all well-known as adequate large biomedical models, associated or not with gene editing tools, can be used as models on in vivo or in vitro translational research, specifically on regenerative medicine, drug screening, and stem cell therapy.
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