{"title":"单蛋白大面积检测:从机制到临床应用","authors":"L. Torsi","doi":"10.1109/IWASI58316.2023.10164301","DOIUrl":null,"url":null,"abstract":"A large millimeter-wide electronic interface can detect at a single-molecule/entity limit-of-detection. The technology is called SiMoT - Single-Molecule with a large Transistor [1]. So far, antigens (Immunoglobulins, C-reactive proteins, spike 1, HIV p-24), antibodies (anti-immunoglobulins, anti-spike1), peptides, viruses (SARS-Cov-2), bacteria (Xylella fastidiosa), and even DNA strands (KRAS, miR-182) have been detected. Selectivity is assured by covering the gate electrode with a large number (1011-1012/cm2) of recognition elements to affinity binding the target element.","PeriodicalId":261827,"journal":{"name":"2023 9th International Workshop on Advances in Sensors and Interfaces (IWASI)","volume":"51 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Single-protein large area detections: from mechanism to applications in the clinics\",\"authors\":\"L. Torsi\",\"doi\":\"10.1109/IWASI58316.2023.10164301\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A large millimeter-wide electronic interface can detect at a single-molecule/entity limit-of-detection. The technology is called SiMoT - Single-Molecule with a large Transistor [1]. So far, antigens (Immunoglobulins, C-reactive proteins, spike 1, HIV p-24), antibodies (anti-immunoglobulins, anti-spike1), peptides, viruses (SARS-Cov-2), bacteria (Xylella fastidiosa), and even DNA strands (KRAS, miR-182) have been detected. Selectivity is assured by covering the gate electrode with a large number (1011-1012/cm2) of recognition elements to affinity binding the target element.\",\"PeriodicalId\":261827,\"journal\":{\"name\":\"2023 9th International Workshop on Advances in Sensors and Interfaces (IWASI)\",\"volume\":\"51 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2023 9th International Workshop on Advances in Sensors and Interfaces (IWASI)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/IWASI58316.2023.10164301\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2023 9th International Workshop on Advances in Sensors and Interfaces (IWASI)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/IWASI58316.2023.10164301","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Single-protein large area detections: from mechanism to applications in the clinics
A large millimeter-wide electronic interface can detect at a single-molecule/entity limit-of-detection. The technology is called SiMoT - Single-Molecule with a large Transistor [1]. So far, antigens (Immunoglobulins, C-reactive proteins, spike 1, HIV p-24), antibodies (anti-immunoglobulins, anti-spike1), peptides, viruses (SARS-Cov-2), bacteria (Xylella fastidiosa), and even DNA strands (KRAS, miR-182) have been detected. Selectivity is assured by covering the gate electrode with a large number (1011-1012/cm2) of recognition elements to affinity binding the target element.
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