{"title":"原卟啉IX (PPIX)猝灭纳米乳的荧光研究","authors":"Maurice O Iwunze","doi":"10.15406/mseij.2022.06.00185","DOIUrl":null,"url":null,"abstract":"Nanoemulsion is a unique and versatile fluid that solubilizes both ionic and non-ionic molecules. It has been used extensively for drug delivery. Nanoemulsion, prepared with water-oil-surfactant and co-surfactant, is fluorescent at or the near IR region of electromagnetic spectrum. However, when protoporphyrin (PPIX), a useful photosensitizer in PDT modality, and a poorly water-soluble compound, is introduced into the nanoemulsion medium, the observed fluorescence of the nanoemulsion is quenched. We have used the steady-state fluorescence technique to study the mechanism of this quenching. It is observed that the interaction between nanoemulsion and PPIX is 1:1 and the interaction constant, Ka, is about 2.37 x 105/mol and the Free energy of interactions, Ga, is -30.66 kJ/mol.","PeriodicalId":435904,"journal":{"name":"Material Science & Engineering International Journal","volume":"32 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The fluorescence study of the quenching of nanoemulsion by protoporphyrin IX (PPIX)\",\"authors\":\"Maurice O Iwunze\",\"doi\":\"10.15406/mseij.2022.06.00185\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Nanoemulsion is a unique and versatile fluid that solubilizes both ionic and non-ionic molecules. It has been used extensively for drug delivery. Nanoemulsion, prepared with water-oil-surfactant and co-surfactant, is fluorescent at or the near IR region of electromagnetic spectrum. However, when protoporphyrin (PPIX), a useful photosensitizer in PDT modality, and a poorly water-soluble compound, is introduced into the nanoemulsion medium, the observed fluorescence of the nanoemulsion is quenched. We have used the steady-state fluorescence technique to study the mechanism of this quenching. It is observed that the interaction between nanoemulsion and PPIX is 1:1 and the interaction constant, Ka, is about 2.37 x 105/mol and the Free energy of interactions, Ga, is -30.66 kJ/mol.\",\"PeriodicalId\":435904,\"journal\":{\"name\":\"Material Science & Engineering International Journal\",\"volume\":\"32 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Material Science & Engineering International Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15406/mseij.2022.06.00185\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Material Science & Engineering International Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/mseij.2022.06.00185","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The fluorescence study of the quenching of nanoemulsion by protoporphyrin IX (PPIX)
Nanoemulsion is a unique and versatile fluid that solubilizes both ionic and non-ionic molecules. It has been used extensively for drug delivery. Nanoemulsion, prepared with water-oil-surfactant and co-surfactant, is fluorescent at or the near IR region of electromagnetic spectrum. However, when protoporphyrin (PPIX), a useful photosensitizer in PDT modality, and a poorly water-soluble compound, is introduced into the nanoemulsion medium, the observed fluorescence of the nanoemulsion is quenched. We have used the steady-state fluorescence technique to study the mechanism of this quenching. It is observed that the interaction between nanoemulsion and PPIX is 1:1 and the interaction constant, Ka, is about 2.37 x 105/mol and the Free energy of interactions, Ga, is -30.66 kJ/mol.