生物边界和生物年龄:变分问题的解决方案

J. Demongeot
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引用次数: 0

摘要

如果我们考虑一个有机体的年岁,它往往不能提供有关其发育或衰老过程阶段的有用信息。然后,我们在这里建议使用一个生物年龄,本质上是由一个生物的关键器官组织在海弗利克极限之前使用的有丝分裂的数量决定的(在这种意义上,它们的丧失会导致整个有机体的死亡)。我们提出了一个器官的生物年龄的定义基于海弗利克的极限和一个不同步指数(细胞熵)的组织。
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Biological Boundaries and Biological Age: Solutions of Variational Problems
If we consider the chronologic age of an organism, it is often unable to give useful information about its stage in the development or aging processes. Then we propose here to use a biological age essentially determined by the number of used mitoses before the Hayflick's limit for the tissues of the critical organs (in the sense where their loss causes the death of the whole organism) of a living being. We propose a definition of the biological age of an organ based on the Hayflick's limit and on a desynchronization index (the cell entropy) of its tissues.
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