抑制鸡胚成纤维细胞亚精胺合酶的作用

Cell biology international reports Pub Date : 1992-04-01 DOI:10.1016/S0309-1651(06)80140-2

A. Caruso , A. Pellati , P. Bosi , N. Arena , G. Stabellini

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引用次数: 5

摘要

将亚精胺合成酶抑制剂双环己基硫酸铵(BCHS)用于鸡胚成纤维细胞体外培养，可导致细胞亚精胺水平降低，腐胺和精胺水平升高。细胞增殖率和DNA合成也受到抑制。由于蛋白质合成没有改变，低水平的细胞亚精胺似乎抑制了细胞生长，抑制了DNA合成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effects of spermidine synthase inhibition in cultured chick embryo fibroblasts

The administration of bis-cyclohexylammonium sulfate (BCHS), a spermidine synthase inhibitor, to in vitro cultures of chick embryo fibroblasts caused a decrease in cellular spermidine levels and an increase in putrescine and spermine. Cell proliferation rate and DNA synthesis were also inhibited. As protein synthesis did not change, it would seem that low levels of cellular spermidine inhibit cell growth depressing DNA synthesis.

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Cell biology international reports

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