GARNET试验中dostarlimumab对PD-L1的抗肿瘤活性和错配修复缺陷和精通肿瘤患者的肿瘤突变负担

Susana Banerjee, T. André, D. Berton, S. Ellard, B. Jímenez, V. Samouëlian, L. Gilbert, V. Boni, Xinwei Han, G. Antony, J. Veneris, A. Oaknin
{"title":"GARNET试验中dostarlimumab对PD-L1的抗肿瘤活性和错配修复缺陷和精通肿瘤患者的肿瘤突变负担","authors":"Susana Banerjee, T. André, D. Berton, S. Ellard, B. Jímenez, V. Samouëlian, L. Gilbert, V. Boni, Xinwei Han, G. Antony, J. Veneris, A. Oaknin","doi":"10.1136/ijgc-2022-esgo.878","DOIUrl":null,"url":null,"abstract":"with mismatch repair deficient (dMMR) recurrent/advanced endometrial cancer (EC) that has progressed on or after platinum-based chemotherapy or solid tumours that have progressed on or after prior treatment, with no satisfactory alternative treatment options. We report a post hoc analysis of antitumour activity by PDL1 expression and tumour mutational burden (TMB) in patients with dMMR and MMR proficient (MMRp) solid tumours in the GARNET trial.","PeriodicalId":406851,"journal":{"name":"Translational research/biomarkers","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"2022-RA-945-ESGO Antitumour activity of dostarlimab by PD-L1 and tumour mutation burden in patients with mismatch repair deficient and proficient tumours in the GARNET trial\",\"authors\":\"Susana Banerjee, T. André, D. Berton, S. Ellard, B. Jímenez, V. Samouëlian, L. Gilbert, V. Boni, Xinwei Han, G. Antony, J. Veneris, A. Oaknin\",\"doi\":\"10.1136/ijgc-2022-esgo.878\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"with mismatch repair deficient (dMMR) recurrent/advanced endometrial cancer (EC) that has progressed on or after platinum-based chemotherapy or solid tumours that have progressed on or after prior treatment, with no satisfactory alternative treatment options. We report a post hoc analysis of antitumour activity by PDL1 expression and tumour mutational burden (TMB) in patients with dMMR and MMR proficient (MMRp) solid tumours in the GARNET trial.\",\"PeriodicalId\":406851,\"journal\":{\"name\":\"Translational research/biomarkers\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational research/biomarkers\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1136/ijgc-2022-esgo.878\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational research/biomarkers","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/ijgc-2022-esgo.878","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

错配修复缺陷(dMMR)复发/晚期子宫内膜癌(EC),在铂基化疗中或之后进展,或在先前治疗中或之后进展的实体肿瘤,没有令人满意的替代治疗方案。我们报告了GARNET试验中dMMR和MMR精通(MMRp)实体瘤患者的PDL1表达和肿瘤突变负担(TMB)的抗肿瘤活性的事后分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
2022-RA-945-ESGO Antitumour activity of dostarlimab by PD-L1 and tumour mutation burden in patients with mismatch repair deficient and proficient tumours in the GARNET trial
with mismatch repair deficient (dMMR) recurrent/advanced endometrial cancer (EC) that has progressed on or after platinum-based chemotherapy or solid tumours that have progressed on or after prior treatment, with no satisfactory alternative treatment options. We report a post hoc analysis of antitumour activity by PDL1 expression and tumour mutational burden (TMB) in patients with dMMR and MMR proficient (MMRp) solid tumours in the GARNET trial.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
2022-RA-1360-ESGO Circulatory HMGB-1 as a plausible diagnostic marker in liquid biopsy of cervical cancer 2022-RA-793-ESGO TROP-2 expression and the tumor immune-microenvironment in cervical cancer 2022-RA-366-ESGO Calcium activated potassium channels (KCNMA1) as biomarker of pre invasive and invasive cervical cancer 2022-RA-1651-ESGO Epithelial Ovarian Cancer is infiltrated by activated effector T cells coexpressing multiple inhibitory receptors and by myeloid cells expressing inhibitory receptor ligands 2022-RA-1126-ESGO Mesenchymal prognostic signature in ovarian cancer
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1