Deprescribing Antidepressant Medications in Major Depressive Disorder

This chapter describes the specific considerations for decision-making surrounding the deprescribing of antidepressants. The chapter discusses how to arrive at a risk–benefit ratio that considers the pros and cons of deprescribing antidepressants, common clinical presentations of withdrawal symptoms and their management, and the possible steps that may be taken to prevent a recurrence of a depressive episode, including the use of nonpharmacological interventions. Antidepressants are among the most frequently prescribed psychotropic medications and are prescribed in an ongoing way that may be contrary to current guidelines. Commonly encountered decision points are discussed and illustrated with relevant case examples provided at the end of the chapter.