非o型血与有或无遗传性血栓病妇女早期原因不明的复发性自然流产的关系

Anna Poretto, E. Borella, Giacomo Turatti, M. Marobin, E. Campello, D. Tormene, P. Simioni, L. Spiezia
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摘要

我们回顾性地评估了一组复发性自然流产(RSA)妇女中非o型血(最常见的遗传性血栓形成因子)和遗传性血栓形成(IT)的患病率。所有在2008年12月至2021年12月期间连续接受过信息技术筛查的早期不明原因RSA病史的女性都被考虑纳入研究对象。一组健康、年龄匹配、≥1次正常妊娠且无不良妊娠结局的妇女作为对照组。共有217名妇女参加。非O型血与O型血的RSA校正比值比(aOR)为1.37 (95% CI, 1.04-2.78),有IT的女性与没有IT的女性的RSA校正比值比为1.26 (95% CI, 1.08-3.61);非o型血和IT女性的RSA的aOR为2.52 (95% CI, 1.12-5.47)。我们观察到非o型血或IT与RSA之间存在显著关联。非o型血和IT的同时存在进一步增加了RSA的风险。
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Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia
We retrospectively evaluated the prevalence of non-O blood type – the most frequently inherited prothrombotic factor – and inherited thrombophilia (IT) in a group of women with recurrent spontaneous abortion (RSA). All consecutive women with a history of early unexplained RSA who underwent a screening for IT between December 2008 and December 2021 were considered for enrolment. A group of healthy, age-matched women with ≥1 normal pregnancy and no adverse pregnancy outcomes acted as controls. Two hundred and seventeen women were enrolled. The adjusted odds ratio (aOR) of RSA in non-O vs. O blood type was 1.37 (95% CI, 1.04-2.78), and in women with vs. without IT was 1.26 (95% CI, 1.08-3.61); aOR of RSA in women with non-O blood type and IT was 2.52 (95% CI, 1.12-5.47). We observed a significant association between non-O blood group or IT and RSA. The concomitant presence of non-O blood group and IT further increases RSA risk.
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