N. Hosszúfalusi, M. Kempler
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摘要

摘要:在过去的几十年里,1型糖尿病(T1DM)的死亡率有了很大的提高,根据瑞典数据库,死亡率下降了29%。与一般人群相比,T1DM患者的死亡率仍高出2-8倍,导致20岁个体的平均预期寿命降低12年。最近的研究表明,无论疾病持续时间如何,早期发病与较高的死亡风险相关。死亡的主要原因是心血管死亡。早期降低复杂心血管风险是T1DM患者管理的一个重要方面。它的组成部分是在尽可能低的低血糖发生率下良好的血糖控制,健康的生活方式,定期运动,避免肥胖和吸烟,以及将其他医学上可控的风险因素(如血压,低密度脂蛋白胆固醇和蛋白尿)治疗到目标值。我们总结了基于国家和国际指南的1型糖尿病心血管预防的可用选择,并强调了年轻T1DM患者降低风险的重要性。
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A kardiovaszkuláris kockázat csökkentése 1-es típusú diabetes mellitusban, felnőttkorban
Summary: In the past decades, the mortality of type 1 diabetes mellitus (T1DM) has greatly improved, according to the Swedish database the mortality decreased with 29%. Still there is 2-8-fold higher mortality rate in T1DM compared to the general population, causing an average of 12-year lower life expectancy in a 20- year-old individual. Recent studies suggest that earlier start of the disease is associated with higher mortality risk regardless of disease duration. The leading cause of death is cardiovascular mortality. Early complex cardiovascular risk reduction is an important aspect of the management of patient with T1DM. Its components are the good glycaemic control at the lowest possible incidence of hypoglycaemia, healthy lifestyle, regular exercise, avoidance of obesity and smoking, as well as treating other medically manageable risk factors (such as blood pressure, LDL-cholesterol and albuminuria) to target values. We summarize the available options of cardiovascular prevention in type 1 diabetes mellitus based on national and international guidelines and emphasize the importance of risk reduction among the young patients with T1DM.
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