抗糖尿病中药中苯甲酸钠和山梨酸钾的研究

N. Islam, M. Faruque, R. Zamir
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引用次数: 0

摘要

本研究采用紫外可见分光光度法对部分从当地市场采集的抗糖尿病中草药(adhd)中的苯甲酸钠和山梨酸钾进行了测定。在原料药和制剂中,苯甲酸钠和山梨酸钾分别在224 nm和254.5 nm处测定分析物。校正曲线在苯甲酸钠0 ~ 40 ppm和山梨酸钾0 ~ 50 ppm范围内符合比尔定律,并通过了拟合优度评价。苯甲酸钠的检出限、检出限和定量限分别为0.13 pm和0.40 ppm。检出限、LOD和定量限国家未知。综上所述,就防腐剂而言,草药是否可以安全食用,需要更多的评估。,山梨酸钾的定量限分别为0.28 pm和0.85 ppm。没有样品超过苯甲酸钠和山梨酸钾的安全限值。该国草药中防腐剂含量的总体情况尚不清楚,在本研究中,我们在药物样品中确定了两种防腐剂。综上所述,就防腐剂而言,草药是否可以安全食用,需要更多的评估。
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Investigation of Sodium Benzoate and Potassium Sorbate in Anti-Diabetic Herbal Drugs
The objective of the study was to assess sodium benzoate and potassium sorbate in some anti-diabetic herbal drugs (ADHDs) collected from local markets using UV-Vis spectrophotometric method. Analytes were measured in bulk and finished drug formulations at 224 nm for Sodium benzoate and 254.5 nm for potassium sorbate. The calibration curve obeyed Beer’s law in the range of 0-40 ppm for sodium benzoate and 0-50 ppm for potassium sorbate and passed the goodness of fit evaluation. Limit of detection, LOD and limit of quantification, LOQ for sodium benzoate was 0.13 pm and 0.40 ppm respectively. The limit of detection, LOD and limit of quantification country is unknown. To conclude, whether the herbal drugs are safe to consume in terms of preservatives, more assessment is required., LOQ for potassium sorbate were 0.28 pm and 0.85 ppm respectively. No samples crossed safety limits for sodium benzoate and potassium sorbate. Overall picture of preservative content in herbal drugs of the country is unknown and, in this study, we identified both preservatives in the drug samples. To conclude, whether the herbal drugs are safe to consume in terms of preservatives, more assessment is required.
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